Publications
Detailed Information
MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, S. O. | - |
dc.contributor.author | Jeon, Y. K. | - |
dc.contributor.author | Paik, J. H. | - |
dc.contributor.author | Kim, W. Y. | - |
dc.contributor.author | Kim, Y. A. | - |
dc.contributor.author | Kim, J. E. | - |
dc.contributor.author | Kim, C. W. | - |
dc.date.accessioned | 2023-05-08T08:27:12Z | - |
dc.date.available | 2023-05-08T08:27:12Z | - |
dc.date.created | 2023-05-04 | - |
dc.date.created | 2023-05-04 | - |
dc.date.issued | 2008-08 | - |
dc.identifier.citation | Histopathology, Vol.53 No.2, pp.205-217 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192186 | - |
dc.description.abstract | Aims: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with various genetic alterations. The aim was to investigate MYC, Bcl-2 and Bcl-6 translocations and copy number changes adult DLBCLs to evaluate their clinicopathological features and prognostic implications. Methods and results: Gene status was examined using fluorescence situ hybridization (FISH), and the results were analysed in the context of germinal centre B-cell (GCB) and non-GCB type of DLBCL based on immunohistochemistry. MYC translocation was observed in 9% (14 of 156), and an increased copy number (ICN) in 7.1% (11 of 156). MYC translocation was more common in GCB type (22%)) than in non-GCB type (4.9%), and associated with advanced International Prognostic Index (IPI). MYC aberration, i.e. translocation or increased copy number (ICN), was significantly associated with shorter overall survival, especially for the GCB type. Bcl-2 translocation was rare (3.4%. five of 145), and ICN was observed in 11.7%, (1.7 of 145). more frequently in non-GCB type (16%) than in GCB type (2.5%). Bcl-2 aberration tended to have an adverse effect on Survival. In multivariate analysis, MYC ICN was an independent poor prognostic factor. Conclusions: Analyses of MYC and Bcl-2 status. i.e. translocation and ICN, in the context of DLBCL phenotype might help predict prognosis and therapeutic strategies. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1365-2559.2008.03076.x | - |
dc.citation.journaltitle | Histopathology | - |
dc.identifier.wosid | 000258504400009 | - |
dc.identifier.scopusid | 2-s2.0-47749103376 | - |
dc.citation.endpage | 217 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 205 | - |
dc.citation.volume | 53 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, J. H. | - |
dc.contributor.affiliatedAuthor | Kim, J. E. | - |
dc.contributor.affiliatedAuthor | Kim, C. W. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | PARAFFIN-EMBEDDED TISSUE | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | FOLLICULAR LYMPHOMA | - |
dc.subject.keywordPlus | BURKITTS-LYMPHOMA | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | CHROMOSOMAL-ABNORMALITIES | - |
dc.subject.keywordPlus | NEGATIVE AUTOREGULATION | - |
dc.subject.keywordPlus | CLINICAL-FEATURES | - |
dc.subject.keywordPlus | BCL-2 GENE | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.subject.keywordAuthor | Bcl-6 | - |
dc.subject.keywordAuthor | chromosome translocation | - |
dc.subject.keywordAuthor | diffuse large B cell lymphoma | - |
dc.subject.keywordAuthor | MYC | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.