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Expression and prognostic implications of cell cycle regulatory molecules, p16, p21, p27, p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell lymphomas
DC Field | Value | Language |
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dc.contributor.author | Paik, JH | - |
dc.contributor.author | Jeon, YK | - |
dc.contributor.author | Park, SS | - |
dc.contributor.author | Kim, YA | - |
dc.contributor.author | Kim, JE | - |
dc.contributor.author | Huh, J | - |
dc.contributor.author | Lee, SS | - |
dc.contributor.author | Kim, WH | - |
dc.contributor.author | Kim, CW | - |
dc.date.accessioned | 2023-05-08T08:27:45Z | - |
dc.date.available | 2023-05-08T08:27:45Z | - |
dc.date.created | 2023-05-04 | - |
dc.date.created | 2023-05-04 | - |
dc.date.issued | 2005-09 | - |
dc.identifier.citation | Histopathology, Vol.47 No.3, pp.281-291 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192197 | - |
dc.description.abstract | Aims: To evaluate the different expression patterns and the prognostic significance of cell cycle regulatory molecules in diffuse large B-cell lymphomas (DLBCLs) of germinal centre (GC) and non-GC phenotypes. Methods and results: Tissue microarray slides composed of 126 extranodal and 88 nodal DLBCLs were immunostained for p16, p21, p27, p14 and p53. DLBCLs were classified into GC and non-GC phenotype according to the immunohistochemical expression of bcl-6, CD10, and MUM1. Aberrant expression of p53 was more frequent in the GC phenotype in nodal cases (P = 0.038), and the loss of p16, p21 and p14 expression was significantly more common in the non-GC phenotype (P = 0.004, P = 0.001, P < 0.001). Concurrent disruptions of the p16-Rb and p14-p53 pathways as represented by the immunoprofile of p16/p14/p53 (-/-/+) were associated with a poor prognosis in the GC phenotype [mean survival 31 months in the p16/p14/p53 (-/-/+) group versus 62 months in the other groups, P =0.0485]. Conclusions: The expression and prognostic implications of cell cycle regulatory molecules differ between GC and non-GC phenotypes in DLBCLs. The immunoprofile of p16/p14/p53 (-/-/+) within the GC phenotype of DLBCLs can be defined as a poor prognostic subgroup. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Expression and prognostic implications of cell cycle regulatory molecules, p16, p21, p27, p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell lymphomas | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1365-2559.2005.02222.x | - |
dc.citation.journaltitle | Histopathology | - |
dc.identifier.wosid | 000231394800006 | - |
dc.identifier.scopusid | 2-s2.0-24144456978 | - |
dc.citation.endpage | 291 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 281 | - |
dc.citation.volume | 47 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Paik, JH | - |
dc.contributor.affiliatedAuthor | Kim, JE | - |
dc.contributor.affiliatedAuthor | Kim, WH | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | TISSUE MICROARRAYS | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | KIEL CLASSIFICATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SUBCLASSIFICATION | - |
dc.subject.keywordPlus | P16(INK4A) | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | diffuse large B-cell lymphoma | - |
dc.subject.keywordAuthor | p14/ARF | - |
dc.subject.keywordAuthor | p16/INK4a | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | tissue microarray | - |
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