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Protective effects of an electrophilic metabolite of docosahexaenoic acid on UVB-induced oxidative cell death, dermatitis, and carcinogenesis
DC Field | Value | Language |
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dc.contributor.author | Kim, Seong Hoon | - |
dc.contributor.author | Lee, So Eui | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Fang, Xizhu | - |
dc.contributor.author | Hur, Jihyeon | - |
dc.contributor.author | Sozen, Erdi | - |
dc.contributor.author | Özer, Nesrin Kartal | - |
dc.contributor.author | Kim, Kwang Pyo | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2023-05-10T01:21:33Z | - |
dc.date.available | 2023-05-10T01:21:33Z | - |
dc.date.created | 2023-04-19 | - |
dc.date.created | 2023-04-19 | - |
dc.date.created | 2023-04-19 | - |
dc.date.created | 2023-04-19 | - |
dc.date.created | 2023-04-19 | - |
dc.date.created | 2023-04-19 | - |
dc.date.created | 2023-04-19 | - |
dc.date.created | 2023-04-19 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | Redox Biology, Vol.62, p. 102666 | - |
dc.identifier.issn | 2213-2317 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192240 | - |
dc.description.abstract | Docosahexaenoic acid (DHA), a representative omega-3 (ω-3) polyunsaturated fatty acids, undergoes metabolism to produce biologically active electrophilic species. 17-Oxo-DHA is one such reactive metabolite generated from DHA by cyclooxygenase-2 and dehydrogenase in activated macrophages. The present study was aimed to investigate the effects of 17-oxo-DHA on ultraviolet B (UVB)-induced oxidative stress, inflammation, and carcinogenesis in mouse skin. UVB-induced epidermal cell death was ameliorated by topically applied 17-oxo-DHA. Topical application of 17-oxo-DHA onto hairless mouse skin inhibited UVB-induced phosphorylation of the proinflammatory transcription factor, STAT3 on tyrosine 705 (Tyr705). The 17-oxo-DHA treatment also reduced the levels of oxidative stress markers, 4-hydroxynonenal-modified protein, malondialdehyde, and 8-oxo-2′-deoxyguanosine. The protective effects of 17-oxo-DHA against oxidative damage in UVB-irradiated mouse skin were associated with activation of Nrf2. 17-Oxo-DHA enhanced the engulfment of apoptotic JB6 cells by macrophages, which was related to the increased expression of the scavenger receptor CD36. The 17-oxo-DHA-mediated potentiation of efferocytic activity of macrophages was attenuated by the pharmacologic inhibition or knockout of Nrf2. The pretreatment with 17-oxo-DHA reduced the UVB-induced skin carcinogenesis and tumor angiogenesis. It was also confirmed that 17-oxo-DHA treatment significantly inhibited the phosphorylation of the Tyr705 residue of STAT3 and decreased the expression of its target proteins in cutaneous papilloma. In conclusion, 17-oxo-DHA protects against UVB-induced oxidative cell death, dermatitis, and carcinogenesis. These effects were associated with inhibition of STAT3-mediated proinflammatory signaling and also activation of Nrf2 with subsequent upregulation of antioxidant and anti-inflammatory gene expression. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Protective effects of an electrophilic metabolite of docosahexaenoic acid on UVB-induced oxidative cell death, dermatitis, and carcinogenesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.redox.2023.102666 | - |
dc.citation.journaltitle | Redox Biology | - |
dc.identifier.wosid | 000958292400001 | - |
dc.identifier.scopusid | 2-s2.0-85150256254 | - |
dc.citation.startpage | 102666 | - |
dc.citation.volume | 62 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | MEDIATORS | - |
dc.subject.keywordPlus | STAT3 | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordAuthor | 17-Oxo-DHA | - |
dc.subject.keywordAuthor | Dermatitis | - |
dc.subject.keywordAuthor | Efferocytosis | - |
dc.subject.keywordAuthor | Photocarcinogenesis | - |
dc.subject.keywordAuthor | Resolution of inflammation | - |
dc.subject.keywordAuthor | UVB-induced inflammation | - |
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