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Longitudinal association between adiposity changes and lung function deterioration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Youngmok | - |
dc.contributor.author | Kim, Jiyoung | - |
dc.contributor.author | Kim, Young Sam | - |
dc.contributor.author | Leem, Ah Young | - |
dc.contributor.author | Jo, Jinyeon | - |
dc.contributor.author | Chung, Kyungsoo | - |
dc.contributor.author | Park, Moo Suk | - |
dc.contributor.author | Won, Sungho | - |
dc.contributor.author | Jung, Ji Ye | - |
dc.date.accessioned | 2023-05-11T04:23:42Z | - |
dc.date.available | 2023-05-11T04:23:42Z | - |
dc.date.issued | 2023-02-07 | - |
dc.identifier.citation | Respiratory Research, 24(1):44 | ko_KR |
dc.identifier.issn | 1465-993X | - |
dc.identifier.uri | https://hdl.handle.net/10371/192359 | - |
dc.description.abstract | Background
The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian population. Methods In total, 5011 participants (average age, 54years; 45% men) were enrolled from a community-based prospective cohort. During the follow-up period (median 8years), both spirometry and bio-electrical impedance analysis were performed biannually. Individual slopes of the fat mass index (FMI; fat mass divided by the square of height in meters) and waist-to-hip ratio (WHR) were calculated using linear regression analysis. Multivariate linear mixed regression analysis was used to determine the long-term association between adiposity changes and lung function. Results The FMI was inversely associated with forced vital capacity (FVC) (estimated: − 31.8mL in men, − 27.8mL in women) and forced expiratory volume in 1s (FEV1) (estimated: − 38.2mL in men, − 17.8mL in women) after adjusting for baseline age, height, residential area, smoking exposure (pack-years, men only), initial adiposity indices, and baseline lung function. The WHR was also inversely associated with FVC (estimated = − 1242.2mL) and FEV1 (estimated = − 849.8mL) in men. The WHR-increased group showed a more rapid decline in lung function than the WHR-decreased group in both the fat-gain and fat-loss groups. Conclusion Adiposity was associated with the long-term impairment of lung function. Central obesity was the main driver of lung function impairment in the middle-aged general Asian population, regardless of fat mass changes. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Abdominal obesity | - |
dc.subject | Adiposity | - |
dc.subject | Body composition | - |
dc.subject | Spirometry | - |
dc.subject | Waist–hip ratio | - |
dc.title | Longitudinal association between adiposity changes and lung function deterioration | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12931-023-02322-8 | ko_KR |
dc.citation.journaltitle | Respiratory Research | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2023-03-23T11:16:28Z | - |
dc.citation.number | 44 | ko_KR |
dc.citation.volume | 24 | ko_KR |
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