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Novel thrombospondin-1 transcript exhibits distinctive expression and activity in thyroid tumorigenesis
DC Field | Value | Language |
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dc.contributor.author | Hong, Yukyung | - |
dc.contributor.author | Kim, Ilju | - |
dc.contributor.author | Moon, Hyunjin | - |
dc.contributor.author | Lee, Jaehak | - |
dc.contributor.author | Lertpatipanpong, Pattawika | - |
dc.contributor.author | Ryu, Chang Hwan | - |
dc.contributor.author | Jung, Yuh-Seog | - |
dc.contributor.author | Seok, Jungirl | - |
dc.contributor.author | Kim, Yonghwan | - |
dc.contributor.author | Ryu, Junsun | - |
dc.contributor.author | Baek, Seung Joon | - |
dc.date.accessioned | 2023-05-24T07:27:18Z | - |
dc.date.available | 2023-05-24T07:27:18Z | - |
dc.date.created | 2023-05-19 | - |
dc.date.created | 2023-05-19 | - |
dc.date.created | 2023-05-19 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | Oncogene, Vol.42 No.22, pp.1832-1842 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192459 | - |
dc.description.abstract | Thrombospondin 1 (TSP1) is known for its cell-specific functions in cancer progression, such as proliferation and migration. It contains 22 exons that may potentially produce several different transcripts. Here, we identified TSP1V as a novel TSP1-splicing variant produced by intron retention (IR) in human thyroid cancer cells and tissues. We observed that TSP1V functionally inhibited tumorigenesis contrary to TSP1 wild-type, as identified in vivo and in vitro. These activities of TSP1V are caused by inhibiting phospho-Smad and phospho-focal adhesion kinase. Reverse transcription polymerase chain reaction and minigene experiments revealed that some phytochemicals/non-steroidal anti-inflammatory drugs enhanced IR. We further found that RNA-binding motif protein 5 (RBM5) suppressed IR induced by sulindac sulfide treatment. Additionally, sulindac sulfide reduced phospho-RBM5 levels in a time-dependent manner. Furthermore, trans-chalcone demethylated TSP1V, thereby preventing methyl-CpG-binding protein 2 binding to TSP1V gene. In addition, TSP1V levels were significantly lower in patients with differentiated thyroid carcinoma than in those with benign thyroid nodule, indicating its potential application as a diagnostic biomarker in tumor progression. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Novel thrombospondin-1 transcript exhibits distinctive expression and activity in thyroid tumorigenesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41388-023-02692-9 | - |
dc.citation.journaltitle | Oncogene | - |
dc.identifier.wosid | 000967803500001 | - |
dc.identifier.scopusid | 2-s2.0-85152696835 | - |
dc.citation.endpage | 1842 | - |
dc.citation.number | 22 | - |
dc.citation.startpage | 1832 | - |
dc.citation.volume | 42 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Baek, Seung Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FOLLICULAR NEOPLASM | - |
dc.subject.keywordPlus | ANTICANCER ACTIVITY | - |
dc.subject.keywordPlus | SR PROTEIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordPlus | DOMAIN | - |
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