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Effectiveness of the guava leaf extracts against lipopolysaccharide-induced oxidative stress and immune responses in Cyprinus carpio
DC Field | Value | Language |
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dc.contributor.author | Giri, Sib Sankar | - |
dc.contributor.author | Kim, Hyoun Joong | - |
dc.contributor.author | Kim, Sang Guen | - |
dc.contributor.author | Kim, Sang Wha | - |
dc.contributor.author | Kwon, Jun | - |
dc.contributor.author | Lee, Sung Bin | - |
dc.contributor.author | Sukumaran, V | - |
dc.contributor.author | Park, Se Chang | - |
dc.date.accessioned | 2023-05-30T07:03:03Z | - |
dc.date.available | 2023-05-30T07:03:03Z | - |
dc.date.created | 2020-10-12 | - |
dc.date.created | 2020-10-12 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | Fish and Shellfish Immunology, Vol.105, pp.164-176 | - |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192495 | - |
dc.description.abstract | The anti-inflammatory activity of the guava leaf extracts (GLE) against LPS-induced inflammatory responses in fish macrophage cell lines is well documented. Here, we evaluated the effects of dietary GLE on LPS-induced oxidative stress, immune responses, and glucocorticoid receptor-related gene expression in Cyprinus carpio. Basal diet was supplemented with 0 (control), 100, 150, 200, or 250 mg kg(-1) GLE for eight weeks. Highest (p < 0.05) weight gain rate was obtained in fish group supplemented with 200 mg kg(-1) of GLE. The results showed that superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, lysozyme, and complement C3 decreased, while malondialdehyde level increased in the liver and spleen upon LPS-challenge. Dietary GLE supplementation (especially 200 or 250 mg kg(-1)) alleviated LPS-induced changes. Similarly, GLE (150-250 mg kg(-1)) reversed LPS-induced alteration of serum biochemical parameters such as alkaline phosphatase, aspartate transaminase, alanine transaminase, and myeloperoxidase. LPS treatment markedly induced increased the mRNA levels of TNF-alpha, IL-beta, and NF-kappa B p65 in both the liver and kidney tissues; however, GLE pre-treatment attenuated LPS-induced elicitation of TNF-alpha, IL-beta, and NF-kappa B p65. Moreover, dietary GLE supplementation significantly increased the expression of HSP70 and HSP90, and glucocorticoid receptor in the liver and kidney after LPS challenge. Thus, GLE attenuated LPS-induced inflammation response by up-regulating glucocorticoid receptor-related gene expression in carp. Finally, GLE supplementation reduced carp mortality after LPS-challenge. These results suggest that dietary supplementation with 200 mg kg(-1) GLE is adequate for effectively attenuating LPS-induced oxidative stress and immune-suppressive effects in C. carpio. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Effectiveness of the guava leaf extracts against lipopolysaccharide-induced oxidative stress and immune responses in Cyprinus carpio | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fsi.2020.06.004 | - |
dc.citation.journaltitle | Fish and Shellfish Immunology | - |
dc.identifier.wosid | 000571747700003 | - |
dc.identifier.scopusid | 2-s2.0-85088115377 | - |
dc.citation.endpage | 176 | - |
dc.citation.startpage | 164 | - |
dc.citation.volume | 105 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Se Chang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PSIDIUM-GUAJAVA L. | - |
dc.subject.keywordPlus | LABEO-ROHITA | - |
dc.subject.keywordPlus | GROWTH-PERFORMANCE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | AEROMONAS-HYDROPHILA | - |
dc.subject.keywordPlus | DISEASE RESISTANCE | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | FISH HEALTH | - |
dc.subject.keywordPlus | COMMON CARP | - |
dc.subject.keywordPlus | LPS | - |
dc.subject.keywordAuthor | Guava leaf extract | - |
dc.subject.keywordAuthor | Glucocorticoid receptor | - |
dc.subject.keywordAuthor | HSPs | - |
dc.subject.keywordAuthor | Kidney | - |
dc.subject.keywordAuthor | Serum | - |
dc.subject.keywordAuthor | Oxidative stress | - |
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