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BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells
DC Field | Value | Language |
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dc.contributor.author | Seo, Hyungseok | - |
dc.contributor.author | González-Avalos, Edahí | - |
dc.contributor.author | Zhang, Wade | - |
dc.contributor.author | Ramchandani, Payal | - |
dc.contributor.author | Yang, Chao | - |
dc.contributor.author | Lio, Chan-Wang J. | - |
dc.contributor.author | Rao, Anjana | - |
dc.contributor.author | Hogan, Patrick G. | - |
dc.date.accessioned | 2023-06-01T06:38:56Z | - |
dc.date.available | 2023-06-01T06:38:56Z | - |
dc.date.created | 2023-05-08 | - |
dc.date.created | 2023-05-08 | - |
dc.date.created | 2023-05-08 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | Nature Immunology, Vol.22 No.8, pp.983-995 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.other | 182414 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192600 | - |
dc.description.abstract | The transcription factors nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-1; Fos–Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence of AP-1 imposes a negative feedback program of T cell hyporesponsiveness (exhaustion). Here, we show that basic leucine zipper ATF-like transcription factor (BATF) and interferon regulatory factor 4 (IRF4) cooperate to counter T cell exhaustion in mouse tumor models. Overexpression of BATF in CD8+ T cells expressing a chimeric antigen receptor (CAR) promoted the survival and expansion of tumor-infiltrating CAR T cells, increased the production of effector cytokines, decreased the expression of inhibitory receptors and the exhaustion-associated transcription factor TOX and supported the generation of long-lived memory T cells that controlled tumor recurrence. These responses were dependent on BATF–IRF interaction, since cells expressing a BATF variant unable to interact with IRF4 did not survive in tumors and did not effectively delay tumor growth. BATF may improve the antitumor responses of CAR T cells by skewing their phenotypes and transcriptional profiles away from exhaustion and towards increased effector function. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서형석 | - |
dc.identifier.doi | 10.1038/s41590-021-00964-8 | - |
dc.citation.journaltitle | Nature Immunology | - |
dc.identifier.wosid | 000674567000005 | - |
dc.identifier.scopusid | 2-s2.0-85110929777 | - |
dc.citation.endpage | 995 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 983 | - |
dc.citation.volume | 22 | - |
dc.identifier.sci | 000674567000005 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seo, Hyungseok | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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