Publications
Detailed Information
Presynaptic Dopamine Capacity in Patients with Treatment-Resistant Schizophrenia Taking Clozapine: An [F-18]DOPA PET Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eui Tae | - |
dc.contributor.author | Howes, Oliver D. | - |
dc.contributor.author | Veronese, Mattia | - |
dc.contributor.author | Beck, Katherine | - |
dc.contributor.author | Seo, Seongho | - |
dc.contributor.author | Park, Jin Woo | - |
dc.contributor.author | Lee, Jae Sung | - |
dc.contributor.author | Lee, Yun-Sang | - |
dc.contributor.author | Kwon, Jun Soo | - |
dc.date.accessioned | 2023-06-08T07:48:16Z | - |
dc.date.available | 2023-06-08T07:48:16Z | - |
dc.date.created | 2018-08-14 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | Neuropsychopharmacology, Vol.42 No.4, pp.941-950 | - |
dc.identifier.issn | 0893-133X | - |
dc.identifier.uri | https://hdl.handle.net/10371/192658 | - |
dc.description.abstract | Some patients with schizophrenia show poor response to first-line antipsychotic treatments and this is termed treatment-resistant schizophrenia The differential response to first-line antipsychotic drugs may reflect a different underlying neurobiology. Indeed, a previous study found dopamine synthesis capacity was significantly lower in patients with treatment-resistant schizophrenia However, in this study, the treatment-resistant patients were highly symptomatic, whereas the responsive patients showed no or minimal symptoms. The study could not distinguish whether this was a trait effect or reflected the difference in symptom levels. Thus, we aimed to test whether dopaminergic function is altered in patients with a history of treatment resistance to first-line drugs relative to treatment responders when both groups are matched for symptom severity levels by recruiting treatment-resistant patients currently showed low symptom severity with the clozapine treatment. Healthy controls (n = 12), patients treated with clozapine (n = 12) who had not responded to first-line antipsychotics, and patients who had responded to first-line antipsychotics (n = 12) were recruited. Participants were matched for age and sex and symptomatic severity level in patient groups. Participants' dopamine synthesis capacity was measured by using [F-18]DOPA PET. We found that patients treated with clozapine show lower dopamine synthesis capacity than patients who have responded to first-line treatment (Cohen's d=0.9191 (whole striatum), 0.7781 (associative striatum), 1.0344 (limbic striatum), and 1.0189 (sensorimotor striatum) in line with the hypothesis that the dopaminergic function is linked to treatment response. This suggests that a different neurobiology may underlie treatment-resistant schizophrenia and that dopamine synthesis capacity may be a useful biomarker to predict treatment responsiveness. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Presynaptic Dopamine Capacity in Patients with Treatment-Resistant Schizophrenia Taking Clozapine: An [F-18]DOPA PET Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/npp.2016.258 | - |
dc.citation.journaltitle | Neuropsychopharmacology | - |
dc.identifier.wosid | 000393725600017 | - |
dc.identifier.scopusid | 2-s2.0-85003781916 | - |
dc.citation.endpage | 950 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 941 | - |
dc.citation.volume | 42 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Eui Tae | - |
dc.contributor.affiliatedAuthor | Lee, Jae Sung | - |
dc.contributor.affiliatedAuthor | Kwon, Jun Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MEDIAL PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | DOUBLE-BLIND PET | - |
dc.subject.keywordPlus | ANTIPSYCHOTIC TREATMENT | - |
dc.subject.keywordPlus | 1ST-EPISODE SCHIZOPHRENIA | - |
dc.subject.keywordPlus | EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | DECARBOXYLASE ACTIVITY | - |
dc.subject.keywordPlus | TREATMENT RESPONSE | - |
dc.subject.keywordPlus | CIGARETTE SMOKERS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | HALOPERIDOL | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.