Ostreol A: A new cytotoxic compound isolated from the epiphytic dinollagellate Ostreopsis cf. ovata from the coastal waters of Jeju Island, Korea

Abstract

Ostreol A was isolated from cultures of the epiphytic dinoflagellate Ostreopsis cf. ovata from the coastal waters of Jeju Island, Korea. The compound, a non-palytoxin derivative, has a polyhydroxy chain ending with the primary amino group and contains an amide bond, along with two tetrahydropyran rings in the chain. Its chemical structure was elucidated by nuclear magnetic resonance (NMR) spectroscopy methods and confirmed by mass analysis. The compound exhibited significant cytotoxicity in the brine shrimp lethality test at a concentration of 0.9 mu g/mL. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.