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New azaspiracids in Amphidomataceae (Dinophyceae)

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dc.contributor.authorKrock, Bernd-
dc.contributor.authorTillmann, Urban-
dc.contributor.authorVoss, Daniela-
dc.contributor.authorKoch, Boris P.-
dc.contributor.authorSalas, Rafael-
dc.contributor.authorWitt, Matthias-
dc.contributor.authorPotvin, Eric-
dc.contributor.authorJeong, Hae Jin-
dc.date.accessioned2023-06-08T07:51:22Z-
dc.date.available2023-06-08T07:51:22Z-
dc.date.created2021-03-19-
dc.date.issued2012-10-
dc.identifier.citationToxicon, Vol.60 No.5, pp.830-839-
dc.identifier.issn0041-0101-
dc.identifier.urihttps://hdl.handle.net/10371/192724-
dc.description.abstractAzaspiracids (AZAs) are a group of lipophilic polyether toxins implicated in incidents of shellfish poisoning in humans, particularly in northern Europe, which are produced by the small marine dinoflagellate Azadinium spinosum. Other related species/strains of the Amphidomataceae have not been proven to date to contain any of the known azaspiracids. Closer analyses of these species/strains by triple quadrupole mass spectrometry in the precursor and product ion mode now revealed four new compounds with high similarity to azaspiracids, all of them with a characteristic rn/z 348 fragment but with absence of the m/z 362 fragment. These compounds were detected in three species/strains, i.e. in North Sea isolates of Azadinium poporum (molecular mass: 845.5 Da), in a Korean isolate which has been designated as A. cf. poporum (molecular mass: 857.5 Da) and in Amphidoma languida isolated from Bantry Bay, Ireland (molecular masses: 815.5 and 829.5 Da). Cell quotas of roughly 2-20 fg per cell were in the same range as found for AZA-1/-2 in A. spinosum. Structures for all compounds were proposed by interpretation of fragmentation patterns and high resolution mass measurements using Fourier transform ion cyclotron resonance-mass spectrometry (FTICR-MS). (C) 2012 Elsevier Ltd. All rights reserved.-
dc.language영어-
dc.publisherPergamon Press-
dc.titleNew azaspiracids in Amphidomataceae (Dinophyceae)-
dc.typeArticle-
dc.identifier.doi10.1016/j.toxicon.2012.05.007-
dc.citation.journaltitleToxicon-
dc.identifier.wosid000308121400015-
dc.identifier.scopusid2-s2.0-84863488452-
dc.citation.endpage839-
dc.citation.number5-
dc.citation.startpage830-
dc.citation.volume60-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorJeong, Hae Jin-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusDINOFLAGELLATE GENUS AZADINIUM-
dc.subject.keywordPlusTRAP MASS-SPECTROMETRY-
dc.subject.keywordPlusMYTILUS-EDULIS-
dc.subject.keywordPlusSHELLFISH-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordPlusMUSSELS-
dc.subject.keywordPlusTOXINS-
dc.subject.keywordPlusBIOSYNTHESIS-
dc.subject.keywordPlusCONFIRMATION-
dc.subject.keywordPlusPOPORUM-
dc.subject.keywordAuthorAzaspiracids-
dc.subject.keywordAuthorAzadinium poporum-
dc.subject.keywordAuthorAmphidoma languida-
dc.subject.keywordAuthorLC-MS/MS-
dc.subject.keywordAuthorPhycotoxin-
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  • College of Natural Sciences
  • Department of Earth and Environmental Sciences
Research Area Aquatic Microbial Ecology, Biological Oceanography, Plankton

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