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Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pérez-Acuña, Dayana | - |
dc.contributor.author | Rhee, Ka Hyun | - |
dc.contributor.author | Shin, Soo Jean | - |
dc.contributor.author | Ahn, Jeeyun | - |
dc.contributor.author | Lee, Jee-Young | - |
dc.contributor.author | Lee, Seung-Jae | - |
dc.date.accessioned | 2023-06-28T02:35:48Z | - |
dc.date.available | 2023-06-28T11:36:24Z | - |
dc.date.issued | 2023-05-20 | - |
dc.identifier.citation | Acta Neuropathologica Communications, Vol.11:83 | ko_KR |
dc.identifier.issn | 2051-5960 | - |
dc.identifier.uri | https://hdl.handle.net/10371/192954 | - |
dc.description.abstract | Abstract
Parkinsons disease (PD) is a neurodegenerative disorder characterized by the aggregation of misfolded α-synuclein and progressive spreading of the aggregates from a few discrete regions to wider brain regions. Although PD has been classically considered a movement disorder, a large body of clinical evidence has revealed the progressive occurrence of non-motor symptoms. Patients present visual symptoms in the initial stages of the disease, and accumulation of phospho-α-synuclein, dopaminergic neuronal loss, and retinal thinning has been observed in the retinas of PD patients. Based on such human data, we hypothesized that α-synuclein aggregation can initiate in the retina and spread to the brain through the visual pathway. Here, we demonstrate accumulation of α-synuclein in the retinas and brains of naive mice after intravitreal injection of α-synuclein preformed fibrils (PFFs). Histological analyses showed deposition of phospho-α-synuclein inclusions within the retina 2months after injection, with increased oxidative stress leading to loss of retinal ganglion cells and dopaminergic dysfunction. In addition, we found accumulation of phospho-α-synuclein in cortical areas with accompanying neuroinflammation after 5months. Collectively, our findings suggest that retinal synucleinopathy lesions initiated by intravitreal injection of α-synuclein PFFs spread to various brain regions through the visual pathway in mice. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.title | Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s40478-023-01575-0 | ko_KR |
dc.citation.journaltitle | Acta Neuropathologica Communications | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2023-05-21T03:11:38Z | - |
dc.citation.number | 83 | ko_KR |
dc.citation.volume | 11 | ko_KR |
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