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The function of the hippocampal-prefrontal networks in scene-based working memory : 해마와 전전두엽 신경 네트워크의 장면 자극 기반 작업기억에서의 기능 연구

DC Field Value Language
dc.contributor.advisor이인아-
dc.contributor.author박은혜-
dc.date.accessioned2023-06-29T02:34:10Z-
dc.date.available2023-06-29T02:34:10Z-
dc.date.issued2023-
dc.identifier.other000000174288-
dc.identifier.urihttps://hdl.handle.net/10371/194310-
dc.identifier.urihttps://dcollection.snu.ac.kr/common/orgView/000000174288ko_KR
dc.description학위논문(박사) -- 서울대학교대학원 : 자연과학대학 뇌인지과학과, 2023. 2. 이인아.-
dc.description.abstractWorking memory has been described as a function in which stimulus information is maintained even when the stimulus disappears. By maintaining information on stimuli, goal-directed behaviors can be performed, and task-relevant information can be flexibly changed in various environments. It has been known that the function of maintaining and manipulating information is processed in the prefrontal cortex of the brain. In previous studies using monkeys, there was a deficit in performing working memory tasks in the prefrontal lesion group. Also, as a result of electrophysiological measurement of cellular activity in the frontal lobe, it was observed that cellular activity increased and was maintained in the delay period. The frontal lobe also plays an important role in working memory in rats. Previous studies have argued that the hippocampus and prefrontal cortex play important roles, especially based on the fact that place-associated working memory has problems when the connection between the hippocampus and frontal lobe is blocked. However, in these studies, the analysis of what information is maintained and transmitted while working memory is processed has not been properly verified, and network studies between the dorsal hippocampus and prelimbic cortex, which have no direct connection, have been mainly conducted. I focused my research on the CA1 area of the intermediate hippocampus and the network of the infralimbic cortex, which have direct connectivity. It was confirmed that theta waves, which are known as information transfer mediators between the two regions, increased significantly in the delay phase, and it was confirmed that most of the theta phase-locked cells during the delay phase have choice information. Based on this result, it was found that the relationship between the intermediate hippocampus and infralimbic cortex, unknown in previous studies, plays an important role in the delay phase of working memory, especially in processing choice information.-
dc.description.abstract작업기억은 자극이 사라진 상황에서도 자극에 대한 정보를 유지하는 현상으로 설명되어 왔다. 자극에 대한 정보 유지를 통해 목표 지향적 행동을 수행할 수 있게 되었으며 변화하는 환경에서 필요한 정보를 유연하게 변동할 수 있었다. 이러한 정보를 유지하고 조작하는 기능은 뇌의 전전두엽에서 이루어진다고 알려져 왔다. 원숭이를 사용한 연구들에서는 전두엽 병변 그룹에서 작업기억을 수행하는 것에 문제가 생겼으며, 전기생리학적으로 전두엽의 세포활동을 측정한 결과 지연구간에서 세포 활동이 증가되며 유지되는 것을 관찰하였다. 작업기억을 수행하는 쥐에서도 전두엽이 중요한 역할을 하며, 특히 해마와 전두엽 간의 연결을 차단했을 때 장소 연합 작업기억에 문제가 생겼음을 토대로 이전 연구들에서는 해마와 전두엽이 중요한 역할을 한다고 주장하였다. 그러나 이런 연구들에서는 작업기억이 유지되는 동안 어떤 정보가 유지되고 전달되는지에 대한 분석이 제대로 이루어지지 않고 있으며, 직접적인 연결성이 없는 등쪽 해마와 전변연 피질 사이의 네트워크 연구가 주로 이루어져 왔다. 나는 직접적인 연결성을 가진 중간 해마의 CA1 영역과 변연하 피질의 네트워크에 집중하여 연구를 진행하였다. 두 영역간 정보 전달 매개체로 알려진 세타파가 지연 구간에서 유의미하게 증가하는 것을 확인하였으며, 지연 구간 동안 세타파에 특정 상에 고정되어 활동하는 세포의 대부분이 선택 정보를 가지고 있다는 것을 확인하였다. 이 결과를 토대로 이전 연구들에서 알려지지 않았던 중간 해마와 변연하 피질의 관계가 작업기억의 지연구간에서 중요한 역할을 하며, 특히 선택 정보를 처리하고 있다는 것을 알 수 있었다.-
dc.description.tableofcontentsBackground and Hypothesis 1
Medial prefrontal cortex and working memory 2
Different function of the medial prefrontal cortex subregions 4
Hippocampus and episodic memory 6
Spatial and value representation in the hippocampus 6
Hippocampus and working memory 7
Hypothesis 8
Chapter 1. 9
1.1 Introduction 10
1.2 Materials and Methods 11
1.2.1 Subjects 11
1.2.2 Virtual Reality System 11
1.2.3 Handling and familiarization 14
1.2.4 Simple association task 14
1.2.5 Scene-based no-delay task 14
1.2.6 Scene-based working memory task 15
1.2.7 Surgery 18
1.2.8 Post surgical re-training procedure 20
1.2.9 Drug injection procedure 20
1.2.10 Histology 21
1.3 Results 22
1.3.1 Histological results 22
1.3.2 Behavioral results 24
1.4 Discussion 27
Chapter 2. 29
2.1 Introduction 30
2.2 Materials and Methods 32
2.2.1 Electrophysiology recording 32
2.2.2 Unit isolation 32
2.2.3 Basic firing properties 33
2.2.4 Rate map construction 33
2.2.5 Rate Difference Index 34
2.2.6 Angle value calculation 36
2.3 Results 37
2.3.1 Basic firing properties of the PL and IL 37
2.3.2 The PL and IL cell activities were correlated with scene and choice information in the PBS session but decreased in the MUS session 43
2.3.3 Phase-specific information in the PL and scene-associated choice information maintenance in the IL is disrupted with the iHPC inactivation 48
2.3.4 The choice information is significantly decreased in the delay phase in the IL 53
2.3.5 The dynamic shift of neural correlates between sample and delay phases in the IL decreased with the iHPC inactivation 55
2.4 Discussion 62
Chapter 3. 63
3.1 Introduction 64
3.2 Materials and Methods 65
3.2.1 Tetrode selection 65
3.2.2 Theta phase-locking strength 65
3.2.3 Statistical analysis 66
3.3 Results 67
3.3.1 Theta Power is increased in the IL in the delay phase and this pattern is disappeared when the iHPC is inactivated 67
3.3.2 The strength of the theta phase-locked cell in the delay phase is significantly larger than the sample phase 75
3.3.3 The IL cell activities were mainly correlated with choice information in the PBS session but decreased in the MUS session in the delay phase 79
3.3.4 The PL is related to the scene-associated choice information processing in the delay phase 81
3.3.5 The network of the iHPC to the IL is critical for the choice information processing 81
3.4 Discussion 86
Chapter 4. 88
4.1 Introduction 89
4.2 Results 90
4.2.1 Histological results 90
4.2.2 Basic firing properties of the OFC 91
4.2.3 The OFC cell activities were correlated with choice information in the PBS session but decreased in the MUS session 92
4.3 Discussion 97
General Discussion 98
The function of the iHPC in the scene-based working memory task 99
The projection from the iHPC to the mPFC is strongly targeted to the IL which is the subregion of the mPFC 99
The function of the iHPC to IL network in the scene-based working memory task 100
The function of the OFC in the scene-based working memory task 103
Limitation and Future study 103
Conclusion 104
Bibliography 106
국문초록 118
Acknowledgment 120		-
dc.format.extentxii, 120-
dc.language.isoeng-
dc.publisher서울대학교 대학원-
dc.subjectMedial prefrontal cortex-
dc.subjectHippocampus-
dc.subjectWorking memory-
dc.subjectScene-based task-
dc.subjectVirtual Reality-
dc.subject.ddc612.8233-
dc.titleThe function of the hippocampal-prefrontal networks in scene-based working memory-
dc.title.alternative해마와 전전두엽 신경 네트워크의 장면 자극 기반 작업기억에서의 기능 연구-
dc.typeThesis-
dc.typeDissertation-
dc.contributor.AlternativeAuthorEun-Hye Park-
dc.contributor.department자연과학대학 뇌인지과학과-
dc.description.degree박사-
dc.date.awarded2023-02-
dc.identifier.uciI804:11032-000000174288-
dc.identifier.holdings000000000049▲000000000056▲000000174288▲-
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