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Clinical features of COVID-19 among patients with end-stage renal disease on hemodialysis in the context of high vaccination coverage during the omicron surge period: a retrospective cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Beck, Nam-Seon | - |
dc.contributor.author | Song, Soomin | - |
dc.contributor.author | Park, Taesung | - |
dc.contributor.author | Hong, So-Hyeon | - |
dc.contributor.author | Jeong-Eun, Jang | - |
dc.contributor.author | Kim, Kyoung-Hwan | - |
dc.contributor.author | Im, Joung-Il | - |
dc.contributor.author | Hong, Sae-Yong | - |
dc.date.accessioned | 2023-07-05T06:25:30Z | - |
dc.date.available | 2023-07-05T15:25:51Z | - |
dc.date.issued | 2023-06-27 | - |
dc.identifier.citation | BMC Nephrology,Vol.24:191 | ko_KR |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194713 | - |
dc.description.abstract | Background
We determined the clinical presentation and outcomes of the Omicron variant of severe acute respiratory syndrome coronavirus 2 infection in hemodialysis patients and identified the risk factors for severe coronavirus disease (COVID-19) and mortality in the context of high vaccination coverage. Methods This was a retrospective cohort study involving hemodialysis patients who were vaccinated against COVID-19 during March–September 2022, when the Omicron variant was predominant, and the COVID-19 vaccination rate was high. The proportion of people with severe COVID-19 or mortality was evaluated using univariate logistic regression. Results Eighty-three (78.3%) patients had asymptomatic/mild symptoms, 10 (9.4%) had moderate symptoms, and 13 (12.3%) had severe symptoms. Six (5.7%) patients required intensive care admission, two (1.9%) required mechanical ventilation, and one (0.9%) was kept on high-flow nasal cannula. Of the five (4.7%) mortality cases, one was directly attributed to COVID-19 and four to pre-existing comorbidities. Risk factors for both severe COVID-19 and mortality were advanced age; number of comorbidities; cardiovascular diseases; increased levels of aspartate transaminase, lactate dehydrogenase, blood urea nitrogen/creatinine ratio, brain natriuretic peptide, and red cell distribution; and decreased levels of hematocrit and albumin. Moreover, the number of COVID-19 vaccinations wasa protective factor against both severe disease and mortality. Conclusions Clinical features of hemodialysis patients during the Omicron surge with high COVID-19 vaccination coverage were significant for low mortality. The risk features for severe COVID-19 or mortality were similar to those in the pre-Omicron period in the context of low vaccination coverage. | ko_KR |
dc.description.sponsorship | This work was supported by a research fund of Chung-Ang Jeil Hospital, Chungbuk, South Korea (CAJ-2022-AS 01). Data analysis was supported by the Bio and Medical Technology Development Program of the National Research Foundation, funded by the Korean government (No. 2021M3E5E3081425). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | COVID-19 | - |
dc.subject | COVID-19 vaccination | - |
dc.subject | End-stage renal disease | - |
dc.subject | Hemodialysis | - |
dc.subject | Omicron variant | - |
dc.title | Clinical features of COVID-19 among patients with end-stage renal disease on hemodialysis in the context of high vaccination coverage during the omicron surge period: a retrospective cohort study | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12882-023-03219-w | ko_KR |
dc.citation.journaltitle | BMC Nephrology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2023-07-02T03:11:53Z | - |
dc.citation.number | 191 | ko_KR |
dc.citation.volume | 24 | ko_KR |
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