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Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates
DC Field | Value | Language |
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dc.contributor.author | Hong, So-Hee | - |
dc.contributor.author | Oh, Hanseul | - |
dc.contributor.author | Park, Yong Wook | - |
dc.contributor.author | Kwak, Hye Won | - |
dc.contributor.author | Oh, Eun Young | - |
dc.contributor.author | Park, Hyo-Jung | - |
dc.contributor.author | Kang, Kyung Won | - |
dc.contributor.author | Kim, Green | - |
dc.contributor.author | Koo, Bon-Sang | - |
dc.contributor.author | Hwang, Eun-Ha | - |
dc.contributor.author | Baek, Seung Ho | - |
dc.contributor.author | Park, Hyeong-Jun | - |
dc.contributor.author | Lee, Yu-Sun | - |
dc.contributor.author | Bang, Yoo-Jin | - |
dc.contributor.author | Kim, Jae-Yong | - |
dc.contributor.author | Bae, Seo-Hyeon | - |
dc.contributor.author | Lee, Su Jeen | - |
dc.contributor.author | Seo, Ki-Weon | - |
dc.contributor.author | Kim, Hak | - |
dc.contributor.author | Kwon, Taewoo | - |
dc.contributor.author | Kim, Ji-Hwan | - |
dc.contributor.author | Lee, Seonghwan | - |
dc.contributor.author | Kim, Eunsom | - |
dc.contributor.author | Kim, Yeonhwa | - |
dc.contributor.author | Park, Jae-Hak | - |
dc.contributor.author | Park, Sang-In | - |
dc.contributor.author | Goncalves, Marta | - |
dc.contributor.author | Weon, Byung Mook | - |
dc.contributor.author | Jeong, Haengdueng | - |
dc.contributor.author | Nam, Ki Taek | - |
dc.contributor.author | Hwang, Kyung-Ah | - |
dc.contributor.author | Kim, Jihye | - |
dc.contributor.author | Kim, Hun | - |
dc.contributor.author | Lee, Sang-Myeong | - |
dc.contributor.author | Hong, Jung Joo | - |
dc.contributor.author | Nam, Jae-Hwan | - |
dc.date.accessioned | 2023-07-07T07:57:33Z | - |
dc.date.available | 2023-07-07T07:57:33Z | - |
dc.date.created | 2021-06-07 | - |
dc.date.created | 2021-06-07 | - |
dc.date.created | 2021-06-07 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.citation | Science advances, Vol.7 No.22, p. eabg7156 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194736 | - |
dc.description.abstract | Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), various vaccines are being developed, with most vaccine candidates focusing on the viral spike protein. Here, we developed a previously unknown subunit vaccine comprising the receptor binding domain (RBD) of the spike protein fused with the tetanus toxoid epitope P2 (RBD-P2) and tested its efficacy in rodents and nonhuman primates (NHPs). We also investigated whether the SARS-CoV-2 nucleocapsid protein (N) could increase vaccine efficacy. Immunization with N and RBD-P2 (RBDP2/N) + alum increased T cell responses in mice and neutralizing antibody levels in rats compared with those obtained using RBD-P2 + alum. Furthermore, in NHPs, RBD-P2/N + alum induced slightly faster SARS-CoV-2 clearance than that induced by RBD-P2 + alum, albeit without statistical significance. Our study supports further development of RBD-P2 as a vaccine candidate against SARS-CoV-2. Also, it provides insights regarding the use of N in protein-based vaccines against SARS-CoV-2. | - |
dc.language | 영어 | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciadv.abg7156 | - |
dc.citation.journaltitle | Science advances | - |
dc.identifier.wosid | 000655906900034 | - |
dc.identifier.scopusid | 2-s2.0-85106973854 | - |
dc.citation.number | 22 | - |
dc.citation.startpage | eabg7156 | - |
dc.citation.volume | 7 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Jae-Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CORONAVIRUS | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | SPIKE | - |
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