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Improved human hematopoietic reconstitution in HepaRG co-transplanted humanized NSG mice
Cited 3 time in
Web of Science
Cited 3 time in Scopus
- Authors
- Issue Date
- 2020-09-30
- Publisher
- 생화학분자생물학회
- Citation
- BMB Reports, Vol.53 No.9, pp.466-471
- Abstract
- Several humanized mouse models are being used to study human-specific immune responses and diseases. However, the pivotal needs of fetal tissues for the humanized mice model have been huddled because of the demand for ethical and medical approval. Thus, we have verified the hematopoietic and immunomodulatory function of HepaRG and developed a new and easy humanized mouse model to replace the use of fetal liver tissue. HepaRG co-transplanted Hu-NSG mice significantly increased CD45+ lymphocytes and CD19+ B cells and CD3+ T cells than normal Hu-NSG, suggesting enhanced reconstitution of the human immune system. These results have improved the applicability of humanized mice by developing new models easily accessible.
- ISSN
- 1976-6696
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