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TRIF Deficiency does not Affect Severity of Ovalbumin-induced Airway Inflammation in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae-Hyoun | - |
dc.contributor.author | Kim, Dong-Jae | - |
dc.contributor.author | Park, Jae Hak | - |
dc.contributor.author | Park, Jong-Hwan | - |
dc.date.accessioned | 2023-07-07T08:00:01Z | - |
dc.date.available | 2023-07-07T08:00:01Z | - |
dc.date.created | 2020-11-13 | - |
dc.date.created | 2020-11-13 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | Immune Network, Vol.14 No.5, pp.249-254 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194787 | - |
dc.description.abstract | Allergic asthma is a chronic pulmonary inflammatory diseasecharacterized by reversible airway obstruction, hyperresponsivenessand eosinophils infiltration. Toll-like receptors(TLRs) signaling are closely associated with asthmaand have emerged as a novel therapeutic target in allergicdisease. The functions of TLR3 and TLR4 in allergic airway inflammationhave been studied; however, the precise role ofTIR-domain-containing adapter-inducing interferon-β (TRIF),the adaptor molecule for both TLR3 and TLR4, is not yet fullyunderstood. To investigate this, we developed a mouse modelof OVA-induced allergic airway inflammation and comparedthe severity of allergic airway inflammation in WT andTRIF?/? mice. Histopathological assessment revealed thatthe severity of inflammation in airway inflammation inTRIF-deficient mice was comparable to that in WT mice. Thetotal number of cells recovered from bronchoalveolar lavagefluid did not differ between WT and TRIF-deficient mice. Moreover, TRIF deficiency did not affect Th1 and Th2 cytokineproduction in lung tissue nor the level of serumOVA-specific IgE, IgG1 and IgG2c. These findings suggestthat TRIF-mediated signaling may not be critical for the developmentof allergic airway inflammation. | - |
dc.language | 영어 | - |
dc.publisher | 대한면역학회 | - |
dc.title | TRIF Deficiency does not Affect Severity of Ovalbumin-induced Airway Inflammation in Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.4110/in.2014.14.5.249 | - |
dc.citation.journaltitle | Immune Network | - |
dc.citation.endpage | 254 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 249 | - |
dc.citation.volume | 14 | - |
dc.identifier.kciid | ART001922089 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Jae Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | TRIF, Allergic airway inflammation, Th2 | - |
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