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Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation
DC Field | Value | Language |
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dc.contributor.author | Jang, Hwan-Hee | - |
dc.contributor.author | Park, Mi-Young | - |
dc.contributor.author | Kim, Heon-Woong | - |
dc.contributor.author | Lee, Young-Min | - |
dc.contributor.author | Hwang, Kyung-A | - |
dc.contributor.author | Park, Jae-Hak | - |
dc.contributor.author | Park, Dong-Sik | - |
dc.contributor.author | Kwon, Oran | - |
dc.date.accessioned | 2023-07-07T08:00:53Z | - |
dc.date.available | 2023-07-07T08:00:53Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.citation | Nutrition and Metabolism, Vol.9, p. 27 | - |
dc.identifier.issn | 1743-7075 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194806 | - |
dc.description.abstract | Background: Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to examine the effects of black rice extract (BRE) on hepatic steatosis and insulin resistance in high-fat diet-fed mice, providing a model of NAFLD. Methods: Twenty-four mice were randomly divided into three groups (n = 8 in each group): normal fat diet (ND), high fat diet (HF), and high fat diet supplemented with 1% (w/w) BRE (HF + 1% BRE). The experimental diets were fed for seven weeks. Results: A HF induced hepatic steatosis with significant increases in the serum levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (TC), and insulin. By contrast, supplementary BRE (10 g/kg of diet) included in the HF alleviated hepatic steatosis and significantly decreased serum TG and TC levels (p < 0.01 for both). Dietary BRE also increased expression of fatty acid metabolism-related genes, including carnitine palmitoyltransferase (CPT1A), acyl-CoA oxidase (ACO), cytochrome P450 (CYP4A10), and peroxisome proliferator activated receptor (PPAR)-alpha (p < 0.05 for all). Conclusions: Dietary BRE supplementation improved serum lipid profiles and significantly enhanced mRNA expression levels of fatty acid metabolism-related genes, primarily via beta-oxidation and omega-oxidation in the liver. Taken together, these findings suggest that a BRE-supplemented diet could be useful in reducing the risks of hepatic steatosis and related disorders, including hyperlipidemia and hyperglycemia. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/1743-7075-9-27 | - |
dc.citation.journaltitle | Nutrition and Metabolism | - |
dc.identifier.wosid | 000304763900001 | - |
dc.identifier.scopusid | 2-s2.0-84859091966 | - |
dc.citation.startpage | 27 | - |
dc.citation.volume | 9 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Jae-Hak | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ATHEROSCLEROTIC PLAQUE-FORMATION | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | PPAR-ALPHA | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | HYPERLIPIDEMIA | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordAuthor | Black rice | - |
dc.subject.keywordAuthor | Cyanidin-3-glucoside | - |
dc.subject.keywordAuthor | Hepatic steatosis | - |
dc.subject.keywordAuthor | High-fat diet | - |
dc.subject.keywordAuthor | Fatty acid oxidation | - |
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