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Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression: possible mechanism for anti-atherogenic effect of Agastache rugosa : Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa
DC Field | Value | Language |
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dc.contributor.author | Hong, JJ | - |
dc.contributor.author | Choi, JH | - |
dc.contributor.author | Oh, SR | - |
dc.contributor.author | Lee, HK | - |
dc.contributor.author | Park, JH | - |
dc.contributor.author | Lee, KY | - |
dc.contributor.author | Kim, JJ | - |
dc.contributor.author | Jeong, TS | - |
dc.contributor.author | Oh, GT | - |
dc.date.accessioned | 2023-07-07T08:05:06Z | - |
dc.date.available | 2023-07-07T08:05:06Z | - |
dc.date.created | 2022-05-13 | - |
dc.date.issued | 2001-04 | - |
dc.identifier.citation | FEBS Letters, Vol.495 No.3, pp.142-147 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194899 | - |
dc.description.abstract | Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover. A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that titianin (100 muM), a major component of A. rugosa inhibits the tumor necrotic factor-alpha (TNF-alpha)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 muM) reduced TNF-alpha -induced activation of nuclear factor-kappaB in HUVECs. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression: possible mechanism for anti-atherogenic effect of Agastache rugosa | - |
dc.title.alternative | Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0014-5793(01)02379-1 | - |
dc.citation.journaltitle | FEBS Letters | - |
dc.identifier.wosid | 000168521700002 | - |
dc.identifier.scopusid | 2-s2.0-0035957698 | - |
dc.citation.endpage | 147 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 142 | - |
dc.citation.volume | 495 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, JH | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RECEPTOR-DEFICIENT MICE | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | ATHEROSCLEROTIC LESIONS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | RABBIT | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordAuthor | atherosclerosis | - |
dc.subject.keywordAuthor | tilianin | - |
dc.subject.keywordAuthor | vascular cell adhesion molecule-1 | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | Agastache rugosa | - |
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