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Enantioselective Synthesis of (+)-Coerulescine by a Phase-Transfer Catalytic Allylation of Diphenylmethyl tert-Butyl α-(2-Nitrophenyl)Malonate : Enantioselective Synthesis of (+)-Coerulescine by a Phase-Transfer Catalytic Allylation of Diphenylmethyl tert-Butyl alpha-(2-Nitrophenyl)Malonate
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sangki | - |
dc.contributor.author | Yang, Jewon | - |
dc.contributor.author | Yang, Sehun | - |
dc.contributor.author | Lee, Geumwoo | - |
dc.contributor.author | Oh, Daehyun | - |
dc.contributor.author | Ha, Min Woo | - |
dc.contributor.author | Hong, Suckchang | - |
dc.contributor.author | Park, Hyeung-geun | - |
dc.date.accessioned | 2023-07-10T07:08:05Z | - |
dc.date.available | 2023-07-10T07:08:05Z | - |
dc.date.created | 2020-12-15 | - |
dc.date.created | 2020-12-15 | - |
dc.date.issued | 2020-11-12 | - |
dc.identifier.citation | Frontiers in Chemistry, Vol.8, p. 577371 | - |
dc.identifier.issn | 2296-2646 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194991 | - |
dc.description.abstract | A 7-step enantioselective synthetic method for preparing (S)(+)-coerulescine is reported through the use of diphenylmethyl tert-butyl alpha-(2-nitrophenyl)malonate (16% overall yield, >99% ee). Allylation is the key step under phase-transfer catalytic conditions (86% ee). This synthetic method can be used as a practical route for the synthesis of various derivatives of (S)(+)-coerulescine for analyzing its structure-activity relationships against its biological activities. | - |
dc.language | 영어 | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Enantioselective Synthesis of (+)-Coerulescine by a Phase-Transfer Catalytic Allylation of Diphenylmethyl tert-Butyl α-(2-Nitrophenyl)Malonate | - |
dc.title.alternative | Enantioselective Synthesis of (+)-Coerulescine by a Phase-Transfer Catalytic Allylation of Diphenylmethyl tert-Butyl alpha-(2-Nitrophenyl)Malonate | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fchem.2020.577371 | - |
dc.citation.journaltitle | Frontiers in Chemistry | - |
dc.identifier.wosid | 000592425400001 | - |
dc.identifier.scopusid | 2-s2.0-85096759101 | - |
dc.citation.startpage | 577371 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hong, Suckchang | - |
dc.contributor.affiliatedAuthor | Park, Hyeung-geun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | OXINDOLES | - |
dc.subject.keywordPlus | PHALARINE | - |
dc.subject.keywordAuthor | coerulescine | - |
dc.subject.keywordAuthor | enantioselective | - |
dc.subject.keywordAuthor | synthesis | - |
dc.subject.keywordAuthor | phase-transfer catalysis | - |
dc.subject.keywordAuthor | alkylation | - |
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