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Tannic acid-functionalized boron nitride nanosheets for theranostics
DC Field | Value | Language |
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dc.contributor.author | Shim, Gayong | - |
dc.contributor.author | Ko, Seungbeom | - |
dc.contributor.author | Park, Joo Yeon | - |
dc.contributor.author | Suh, Ju Han | - |
dc.contributor.author | Quoc-Viet Le | - |
dc.contributor.author | Kim, Dongyoon | - |
dc.contributor.author | Kim, Young Bong | - |
dc.contributor.author | Im, Geun Ho | - |
dc.contributor.author | Kim, Hun Nyun | - |
dc.contributor.author | Choe, Yearn Seong | - |
dc.contributor.author | Cho, Jihee | - |
dc.contributor.author | Kim, Sanghee | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.date.accessioned | 2023-07-10T07:08:08Z | - |
dc.date.available | 2023-07-10T07:08:08Z | - |
dc.date.created | 2020-12-31 | - |
dc.date.created | 2020-12-31 | - |
dc.date.issued | 2020-11-10 | - |
dc.identifier.citation | Journal of Controlled Release, Vol.327, pp.616-626 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://hdl.handle.net/10371/194992 | - |
dc.description.abstract | Here, we report a tannic acid-Fe3+ coordination complex coating that confers magnetic resonance imaging (MRI) theranostic properties to inert nanomaterials. Boron nitride nanosheets (BNS), which lack magnetic field and light responsiveness, were used as a model nonfunctional nanomaterial. Among various catechol derivatives tested (i.e., dopamine, 3,4-dihydroxyphenylacetic acid, gallic acid, and tannic acid), a coating of tannic acid-Fe3+ coordination complex provided the highest magnetic field relaxivity and near infrared (NIR) laser light responsiveness. An in vitro study showed that KB tumor cells treated with tannic acid-Fe3+ coordination complex adsorbed on BNS (TA-Fe/BNS) exhibited higher T1-weighted magnetic resonance contrast compared with plain BNS, and BNS coated with tannic acid or Fe alone. NIR irradiation at 808 nm caused a significant increase in KB tumor cell death after treatment with TA-Fe/BNS compared with other treatments. In vivo MRI imaging revealed tumor accumulation of intravenously administered TA-Fe/BNS. Guided by MRI information, application of focused laser irradiation onto tumor tissues resulted in complete tumor ablation. These results support the potential of TA-Fe/BNS for MRI theranostics. Moreover, this study suggests the wide applicability of TA-Fe noncovalent coating as biocompatible and facile tool for converting nonfunctional early-generation nanomaterials into functional new nanomaterials, opening new opportunities for their use in translational biomedical applications such as MRI theranostics. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Tannic acid-functionalized boron nitride nanosheets for theranostics | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jconrel.2020.09.009 | - |
dc.citation.journaltitle | Journal of Controlled Release | - |
dc.identifier.wosid | 000585933700044 | - |
dc.identifier.scopusid | 2-s2.0-85090737356 | - |
dc.citation.endpage | 626 | - |
dc.citation.startpage | 616 | - |
dc.citation.volume | 327 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Sanghee | - |
dc.contributor.affiliatedAuthor | Oh, Yu-Kyoung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTICANCER DRUG | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordAuthor | Functionalization | - |
dc.subject.keywordAuthor | Boron nitride nanosheets | - |
dc.subject.keywordAuthor | Tannic acid-iron coordination complex | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Theranostics | - |
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