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Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in IκB-ζ-deficient mice : Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in I kappa B-zeta-deficient mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Junho | - |
dc.contributor.author | Alam, Jehan | - |
dc.contributor.author | Choi, Eunji | - |
dc.contributor.author | Ko, Yeon Kyeong | - |
dc.contributor.author | Lee, Ahreum | - |
dc.contributor.author | Choi, Youngnim | - |
dc.date.accessioned | 2023-07-11T01:29:11Z | - |
dc.date.available | 2023-07-11T01:29:11Z | - |
dc.date.created | 2021-02-26 | - |
dc.date.issued | 2020-10-30 | - |
dc.identifier.citation | npj Biofilms and Microbiomes, Vol.6 No.1, p. 49 | - |
dc.identifier.issn | 2055-5008 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195023 | - |
dc.description.abstract | Mice lacking I kappa B-zeta, a protein encoded by the Nfkbiz gene, spontaneously develop a Sjogren's syndrome-like disease involving the lachrymal glands, but no salivary gland symptoms have been reported. We found that Nfkbiz(-/-) female mice presented a significantly reduced salivary flow rate, focal lymphocytic sialadenitis (FLS), and a dysbiotic oral microbiota at week 24. To dissect the contributions of genetic and environmental factors to the salivary gland phenotype, Nfkbiz(+/+) and Nfkbiz(-/-) mice were cohoused after weaning and evaluated at week 20. Cohousing alleviated the salivary gland phenotype of Nfkbiz(-/-) mice but did not induce any disease phenotype in Nfkbiz(+/+) mice. Additionally, the oral microbiota in the cohoused mice was synchronized toward that in Nfkbiz(+/+) mice. In conclusion, I kappa B-zeta-deficient mice developed hyposalivation and FLS, in which a dysbiotic oral microbiota played an important role. This finding suggests that the dysbiotic oral microbiota could be a therapeutic target. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | Nanyang Technological University | - |
dc.title | Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in IκB-ζ-deficient mice | - |
dc.title.alternative | Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in I kappa B-zeta-deficient mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41522-020-00158-4 | - |
dc.citation.journaltitle | npj Biofilms and Microbiomes | - |
dc.identifier.wosid | 000615118700005 | - |
dc.identifier.scopusid | 2-s2.0-85094651970 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 49 | - |
dc.citation.volume | 6 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Choi, Youngnim | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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