Publications
Detailed Information
Dissociated leg muscle atrophy in amyotrophic lateral sclerosis/motor neuron disease: the 'split-leg' sign
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Young Gi | - |
dc.contributor.author | Choi, Seok-Jin | - |
dc.contributor.author | Hong, Yoon-Ho | - |
dc.contributor.author | Kim, Sung-Min | - |
dc.contributor.author | Shin, Je-Young | - |
dc.contributor.author | Sung, Jung-Joon | - |
dc.date.accessioned | 2023-07-11T01:29:28Z | - |
dc.date.available | 2023-07-11T01:29:28Z | - |
dc.date.created | 2021-02-09 | - |
dc.date.issued | 2020-09-24 | - |
dc.identifier.citation | Scientific Reports, Vol.10 No.1, p. 15661 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195029 | - |
dc.description.abstract | Disproportionate muscle atrophy is a distinct phenomenon in amyotrophic lateral sclerosis (ALS); however, preferentially affected leg muscles remain unknown. We aimed to identify this split-leg phenomenon in ALS and determine its pathophysiology. Patients with ALS (n = 143), progressive muscular atrophy (PMA, n = 36), and age-matched healthy controls (HC, n = 53) were retrospectively identified from our motor neuron disease registry. We analyzed their disease duration, onset region, ALS Functional Rating Scale-Revised Scores, and results of neurological examination. Compound muscle action potential (CMAP) of the extensor digitorum brevis (EDB), abductor hallucis (AH), and tibialis anterior (TA) were reviewed. Defined by CMAP(EDB)/CMAP(AH) (SIEDB) and CMAP(TA)/CMAP(AH) (SITA), respectively, the values of split-leg indices (SI) were compared between these groups. SIEDB was significantly reduced in ALS (p < 0.0001) and PMA (p < 0.0001) compared to the healthy controls (HCs). SITA reduction was more prominent in PMA (p < 0.05 vs. ALS, p < 0.01 vs. HC), but was not significant in ALS compared to the HCs. SI was found to be significantly decreased with clinical lower motor neuron signs (SIEDB), while was rather increased with clinical upper motor neuron signs (SITA). Compared to the AH, TA and EDB are more severely affected in ALS and PMA patients. Our findings help to elucidate the pathophysiology of split-leg phenomenon. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Dissociated leg muscle atrophy in amyotrophic lateral sclerosis/motor neuron disease: the 'split-leg' sign | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-020-72887-7 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000608590000004 | - |
dc.identifier.scopusid | 2-s2.0-85091420786 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 15661 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Sung, Jung-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CORTICAL HYPEREXCITABILITY | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | PROJECTIONS | - |
dc.subject.keywordPlus | RESISTANCE | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.