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Screening ginseng saponins in progenitor cells identifies 20(R)-ginsenoside Rh2 as an enhancer of skeletal and cardiac muscle regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ah Ra | - |
dc.contributor.author | Kim, Seon-Wook | - |
dc.contributor.author | Lee, Ba-Wool | - |
dc.contributor.author | Kim, Kuk-Hwa | - |
dc.contributor.author | Kim, Woong-Hee | - |
dc.contributor.author | Seok, Hong | - |
dc.contributor.author | Lee, Ji-Hyung | - |
dc.contributor.author | Um, JungIn | - |
dc.contributor.author | Yim, Soon-Ho | - |
dc.contributor.author | Ahn, Youngkeun | - |
dc.contributor.author | Jin, Suk-Won | - |
dc.contributor.author | Jung, Da-Woon | - |
dc.contributor.author | Oh, Won Keun | - |
dc.contributor.author | Williams, Darren R. | - |
dc.date.accessioned | 2023-07-11T01:30:03Z | - |
dc.date.available | 2023-07-11T01:30:03Z | - |
dc.date.created | 2020-09-11 | - |
dc.date.issued | 2020-03-18 | - |
dc.identifier.citation | Scientific Reports, Vol.10 No.1, p. 4967 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195041 | - |
dc.description.abstract | Aging is associated with increased prevalence of skeletal and cardiac muscle disorders, such as sarcopenia and cardiac infarction. In this study, we constructed a compendium of purified ginsenoside compounds from Panax ginseng C.A. Meyer, which is a traditional Korean medicinal plant used to treat for muscle weakness. Skeletal muscle progenitor cell-based screening identified three compounds that enhance cell viability, of which 20(R)-ginsenoside Rh-2 showed the most robust response. 20(R)-ginsenoside Rh-2 increased viability in myoblasts and cardiomyocytes, but not fibroblasts or diseaserelated cells. The cellular mechanism was identified as downregulation of cyclin-dependent kinase inhibitor 1B (p27Kip1) via upregulation of Akt1/PKB phosphorylation at serine 473, with the orientation of the 20 carbon epimer being crucially important for biological activity. In zebrafish and mammalian models, 20(R)-ginsenoside Rh-2 enhanced muscle cell proliferation and accelerated recovery from degeneration. Thus, we have identified 20(R)-ginsenoside Rh2 as a p27Kip1 inhibitor that may be developed as a natural therapeutic for muscle degeneration. | - |
dc.language | 영어 | - |
dc.publisher | Nature Research | - |
dc.title | Screening ginseng saponins in progenitor cells identifies 20(R)-ginsenoside Rh2 as an enhancer of skeletal and cardiac muscle regeneration | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-020-61491-4 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000563454700016 | - |
dc.identifier.scopusid | 2-s2.0-85082048302 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 4967 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Won Keun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | DAMMARANE TRITERPENES | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | GINSENOSIDES | - |
dc.subject.keywordPlus | RH2 | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | CONVERSION | - |
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