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Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Chi-Hyun | - |
dc.contributor.author | Lee, Won Woo | - |
dc.contributor.author | Jung, Yun Chan | - |
dc.contributor.author | Shin, Ji-Ae | - |
dc.contributor.author | Hong, Kyoung-Ok | - |
dc.contributor.author | Choi, Sujung | - |
dc.contributor.author | Swarup, Neeti | - |
dc.contributor.author | Kim, Jihoon | - |
dc.contributor.author | Ahn, Min-Hye | - |
dc.contributor.author | Jung, Minjung | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.contributor.author | Jin, Bohwan | - |
dc.date.accessioned | 2023-07-11T01:30:53Z | - |
dc.date.available | 2023-07-11T01:30:53Z | - |
dc.date.created | 2020-04-07 | - |
dc.date.created | 2020-04-07 | - |
dc.date.created | 2020-04-07 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Laboratory Animal Research, Vol.35 No.4, p. 27 | - |
dc.identifier.issn | 1738-6055 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195055 | - |
dc.description.abstract | TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied yet. Here, we attempted to confirm antitumor activity of TW37 in human oral cancer. TW-37 significantly inhibited cell proliferation and increased the number of dead cells in MC-3 and HSC-3 human oral cancer cell lines. TW-37 enhanced apoptosis of both cell lines evidenced by annexin V/propidium iodide double staining, sub-G1 population analysis and the detection of cleaved poly (ADP-ribose) polymerase and caspase-3. In addition, TW-37 markedly downregulated the expression of Bcl-2 protein, while not affecting Bcl-xL or myeloid cell leukemia-1. In vivo, TW-37 inhibited tumor growth in a nude mice xenograft model without any significant liver and kidney toxicities. Collectively, these data reveal that TW-37 may be a promising small molecule to inhibit human oral cancer. | - |
dc.language | 영어 | - |
dc.publisher | 한국실험동물학회 | - |
dc.title | Antitumor effect of TW-37, a BH3 mimetic in human oral cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s42826-019-0028-7 | - |
dc.citation.journaltitle | Laboratory Animal Research | - |
dc.identifier.scopusid | 2-s2.0-85089858383 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 27 | - |
dc.citation.volume | 35 | - |
dc.identifier.kciid | ART002547032 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Sung-Dae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | TW-37, Apoptosis, Bcl-2, Oral cancer | - |
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