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Austalides, Osteoclast Differentiation Inhibitors from a Marine-Derived Strain of the Fungus Penicillium rudallense
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Weihong | - |
dc.contributor.author | Lee, Jusung | - |
dc.contributor.author | Kim, Kwang-Jin | - |
dc.contributor.author | Sung, Youjung | - |
dc.contributor.author | Park, Kyu-Hyung | - |
dc.contributor.author | Oh, Eunseok | - |
dc.contributor.author | Park, Chanyoon | - |
dc.contributor.author | Son, Young-Jin | - |
dc.contributor.author | Kang, Heonjoong | - |
dc.date.accessioned | 2023-07-11T01:37:25Z | - |
dc.date.available | 2023-07-11T01:37:25Z | - |
dc.date.created | 2020-04-10 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | Journal of Natural Products, Vol.82 No.11, pp.3083-3088 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195081 | - |
dc.description.abstract | Four new meroterpenoids, austalides V-X (1-3) and a farnesylated phthalide derivative (4), were isolated from the culture of the marine fungus Penicillium rudallense, together with eight known meroterpenoids derivatives (5-12). Their structures, including absolute configurations, were determined by spectroscopic methods. All of the isolated compounds were evaluated for their inhibitory activities on the receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation. Compounds 1, 2, 5-7, and 10 exhibited potent osteoclast differentiation inhibitory activity with ED50 values of 1.9-2.8 mu M. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Austalides, Osteoclast Differentiation Inhibitors from a Marine-Derived Strain of the Fungus Penicillium rudallense | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jnatprod.9b00690 | - |
dc.citation.journaltitle | Journal of Natural Products | - |
dc.identifier.wosid | 000499741400019 | - |
dc.identifier.scopusid | 2-s2.0-85074966526 | - |
dc.citation.endpage | 3088 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 3083 | - |
dc.citation.volume | 82 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kang, Heonjoong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ASPERGILLUS-USTUS | - |
dc.subject.keywordPlus | THOMII MAIRE | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
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