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Phenotypic and Genetic Relationships between Kidney Function and Carotid Intima-Media Thickness in Koreans: The Healthy Twin Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Kayoung | - |
dc.contributor.author | Sung, Joohon | - |
dc.contributor.author | Lee, Sang Cheol | - |
dc.contributor.author | Park, Seung Woo | - |
dc.contributor.author | Kim, Youn Sic | - |
dc.contributor.author | Lee, Joo Yeon | - |
dc.contributor.author | Song, Yun-Mi | - |
dc.date.accessioned | 2023-07-14T04:31:23Z | - |
dc.date.available | 2023-07-14T04:31:23Z | - |
dc.date.created | 2020-07-24 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | Kidney and Blood Pressure Research, Vol.35 No.4, pp.259-264 | - |
dc.identifier.issn | 1420-4096 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195176 | - |
dc.description.abstract | Background: The phenotypic and genetic relationships between carotid intima-media thickness (CIMT) and estimated glomerular filtration rate (eGFR) or urinary albumin-creatinine ratio (ACR) were evaluated in Korean twins and families. Methods: We recruited 688 participants (296 individual twins and 392 singletons, age 30-74 years) who were without myocardial infarction and stroke among participants in the Healthy Twin Study. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. CIMT was measured using B-mode carotid ultrasound. Covariates were sex, Framingham risk scores, alcohol use, exercise, BMI, high-sensitivity C-reactive protein and triglycerides. Quantitative genetic and linear mixed analyses were performed. Results: In adjusted models there were associations between kidney function and CIMT with [beta] estimates ranging from -0.022 to -0.032 between eGFR and CIMT, and from 0.042-0.060 between ACR and CIMT. The covariate-adjusted heritabilities for eGFR, ACR and composite CIMT were 0.75, 0.32 and 0.45, respectively (p < 0.001). The adjusted genetic correlation between eGFR and CIMT was from -0.20 to -0.28 (p < 0.05), whereas there was no genetic correlation between ACR and CIMT. Conclusion: Kidney function is a surrogate marker of carotid atherosclerosis and further studies of the pleiotropic relationships between CIMT and eGFR are warranted. Copyright (C) 2012 S. Karger AG, Basel | - |
dc.language | 영어 | - |
dc.publisher | S. Karger AG | - |
dc.title | Phenotypic and Genetic Relationships between Kidney Function and Carotid Intima-Media Thickness in Koreans: The Healthy Twin Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000334415 | - |
dc.citation.journaltitle | Kidney and Blood Pressure Research | - |
dc.identifier.wosid | 000303846100009 | - |
dc.identifier.scopusid | 2-s2.0-84862794599 | - |
dc.citation.endpage | 264 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 259 | - |
dc.citation.volume | 35 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Sung, Joohon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GLOMERULAR-FILTRATION-RATE | - |
dc.subject.keywordPlus | URINARY ALBUMIN EXCRETION | - |
dc.subject.keywordPlus | SUBCLINICAL ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | HERITABILITY | - |
dc.subject.keywordPlus | FAMILIES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | GFR | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | Albuminuria | - |
dc.subject.keywordAuthor | Carotid atherosclerosis | - |
dc.subject.keywordAuthor | Genetic variation | - |
dc.subject.keywordAuthor | Glomerular filtration rate | - |
dc.subject.keywordAuthor | Risk factor | - |
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