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Anatomical ablation for small hepatocellular carcinomas using multiple applicators: a preliminary study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jae Hyun | - |
dc.contributor.author | Kim, Hee Soo | - |
dc.contributor.author | Yoon, Jeong Hee | - |
dc.contributor.author | Joo, Ijin | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yu, Su Jong | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.date.accessioned | 2023-09-13T07:53:24Z | - |
dc.date.available | 2023-09-13T16:57:59Z | - |
dc.date.issued | 2023-08-21 | - |
dc.identifier.citation | Cancer Imaging, Vol.23(1):78 | ko_KR |
dc.identifier.issn | 1470-7330 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195539 | - |
dc.description.abstract | Background
Anatomical ablation, defined as thermal ablation of tumor-bearing small portal territories, may provide excellent local tumor control in peripherally-located small hepatocellular carcinomas (HCC), which has been a major concern with percutaneous ablation alone. Purpose To evaluate the technical feasibility and therapeutic outcomes of anatomical ablation using multiple radiofrequency (RF) applicators for the ablation of tumor-bearing small portal territories of peripherally-located small (≤ 4 cm) HCCs. Materials and methods Patients with peripherally-located single HCCs (≤ 4 cm) to be treated with anatomical ablation using multiple RF applicators between January 2020 and March 2022 were enrolled in this prospective study. Anatomical ablation was performed for the index tumor under real-time US-CT/MR fusion imaging guidance, with one or two clustered electrode needles placed across the tumor-bearing portal vein branches. Technical success and complications of anatomical ablations were assessed. Cumulative incidence of local tumor progression (LTP) and recurrence-free survival were estimated using the Kaplan–Meier method. Results Fifty-five HCCs (mean size, 1.77 ± 0.59 cm) in 55 participants (mean age, 66.4 ± 7.7 years; 39 men, 16 women) were treated with anatomical ablation; 98.2% (54/55) technical success was achieved. No major complications were noted. Among the 55 participants, LTP occurred in only one patient who had experienced technical failure of anatomical ablation. Estimated 1- and 2-year cumulative incidences of LTP were 0% and 3.7%, respectively. Five patients developed intrahepatic remote recurrence during the median follow-up period of 19.2 months (range, 3.7–28.8 months); therefore, estimated 1- and 2-year recurrence-free survival was 91.7% and 85.0%, respectively. Conclusion Anatomical ablation using multiple RF applicators provided the excellent results of local tumor control in patients with peripherally-located small (≤ 4 cm) HCCs. | ko_KR |
dc.description.sponsorship | This study received technical support and was supported by a research grant (grant number 06-2016-0590) from STARmed Co., and the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Tumor ablation | - |
dc.subject | Multiple applicators | - |
dc.subject | Image fusion | - |
dc.subject | Anatomical ablation | - |
dc.subject | Hepatocellular carcinoma | - |
dc.title | Anatomical ablation for small hepatocellular carcinomas using multiple applicators: a preliminary study | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s40644-023-00597-0 | ko_KR |
dc.citation.journaltitle | Cancer Imaging | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | International Cancer Imaging Society (ICIS) | - |
dc.date.updated | 2023-08-27T03:11:34Z | - |
dc.citation.volume | 23 | ko_KR |
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