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Injectable biocompatible nanocomposites of Prussian blue nanoparticles and bacterial cellulose as a safe and effective photothermal cancer therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Hwichan | - |
dc.contributor.author | Kim, MinKyu | - |
dc.contributor.author | Lee, Wooseung | - |
dc.contributor.author | Jeon, Miyeon | - |
dc.contributor.author | Lee, Chaedong | - |
dc.contributor.author | Kim, Hoonsub | - |
dc.contributor.author | Im, Hyung-Jun | - |
dc.contributor.author | Piao, Yuanzhe | - |
dc.date.accessioned | 2023-10-11T02:25:35Z | - |
dc.date.available | 2023-10-11T11:27:11Z | - |
dc.date.issued | 2023-10-05 | - |
dc.identifier.citation | Journal of Nanobiotechnology, Vol.21(1):365 | ko_KR |
dc.identifier.issn | 1477-3155 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195759 | - |
dc.description.abstract | Photothermal therapy (PTT) is a novel cancer treatment using a photoabsorber to cause hyperthermia to kill tumors by laser irradiation. Prussian blue nanoparticles (PB NPs) are considered as next-generation photothermal agents due to the facile synthesis and excellent absorption of near-infrared light. Although PB NPs demonstrate remarkable PTT capabilities, their clinical application is limited due to their systemic toxicity. Bacterial cellulose (BC) has been applied to various bio-applications based on its unique properties and biocompatibility. Herein, we design composites with PB NPs and BC as an injectable, highly biocompatible PTT agent (IBC-PB composites). Injectable bacterial cellulose (IBC) is produced through the trituration of BC, with PB NPs synthesized on the IBC surface to prepare IBC-PB composites. IBC-PB composites show in vitro and in vivo photothermal therapeutic effects similar to those of PB NPs but with significantly greater biocompatibility. Specifically, in vitro therapeutic index of IBC-PB composites is 26.5-fold higher than that of PB NPs. Furthermore, unlike PB NPs, IBC-PB composites exhibit no overt toxicity in mice as assessed by blood biochemical analysis and histological images. Hence, it is worth pursuing further research and development of IBC-PB composites as they hold promise as safe and efficacious PTT agents for clinical application. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Prussian blue nanoparticles | - |
dc.subject | Bacterial celluloses | - |
dc.subject | Nanocomposites | - |
dc.subject | Photothermal therapy | - |
dc.subject | Improved biocompatibility | - |
dc.title | Injectable biocompatible nanocomposites of Prussian blue nanoparticles and bacterial cellulose as a safe and effective photothermal cancer therapy | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12951-023-02108-6 | ko_KR |
dc.citation.journaltitle | Journal of Nanobiotechnology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | BioMed Central Ltd., part of Springer Nature | - |
dc.date.updated | 2023-10-08T03:11:46Z | - |
dc.citation.volume | 21 | ko_KR |
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