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A laminin-211-derived bioactive peptide promotes the osseointegration of a sandblasted, large-grit, acid-etched titanium implant
DC Field | Value | Language |
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dc.contributor.author | Choi, Jung-Yoo | - |
dc.contributor.author | Kim, Sungjin | - |
dc.contributor.author | Jo, Seung Bin | - |
dc.contributor.author | Kang, Hyun Ki | - |
dc.contributor.author | Jung, Sung Youn | - |
dc.contributor.author | Kim, Sang Wha | - |
dc.contributor.author | Min, Byung-Moo | - |
dc.contributor.author | Yeo, In-Sung Luke | - |
dc.date.accessioned | 2023-10-30T01:59:22Z | - |
dc.date.available | 2023-10-30T01:59:22Z | - |
dc.date.created | 2020-06-23 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Journal of Biomedical Materials Research - Part A, Vol.108 No.5, pp.1214-1222 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/195950 | - |
dc.description.abstract | Early implant loading is very important for reducing the duration of missing teeth in human patients. The laminin-derived peptide, DLTIDDSYWYRI motif (Ln2-P3), accelerates bone healing. Therefore, to investigate the hypothesis that Ln2-P3 increases the bone response to sandblasted, large-grit, acid-etched (SLA) titanium implants, the effect of the Ln2-P3 peptide on the osseointegration of SLA titanium implants was evaluated in vitro and in vivo. Human osteoblast-like cells were cultured on untreated, scrambled peptide (SP)-treated, and Ln2-P3-treated SLA titanium discs, and the cellular responses of these cells were evaluated. The Ln2-P3 treatment augmented osteoblast attachment and spreading, alkaline phosphatase activity, and the expression of osteogenic marker genes. Furthermore, the untreated and Ln2-P3-treated SLA titanium implants were inserted into the tibiae of rabbits for 9 and 11 days. Compared with the untreated implants, the Ln2-P3-treated implants showed a significantly higher bone-to-implant contact ratio at Day 9 after implantation and an increased bone area. The Ln2-P3 treatment of the SLA titanium implant surface augmented osteoblastic activity and accelerated peri-implant bone formation at the bone-implant interface. Overall, these results indicated that compared with the SLA titanium surface alone, the Ln2-P3 peptide-treated SLA titanium surface enhances initial osseointegration, thereby facilitating earlier implant loading. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | A laminin-211-derived bioactive peptide promotes the osseointegration of a sandblasted, large-grit, acid-etched titanium implant | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jbm.a.36895 | - |
dc.citation.journaltitle | Journal of Biomedical Materials Research - Part A | - |
dc.identifier.wosid | 000513202800001 | - |
dc.identifier.scopusid | 2-s2.0-85079732128 | - |
dc.citation.endpage | 1222 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 1214 | - |
dc.citation.volume | 108 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Sang Wha | - |
dc.contributor.affiliatedAuthor | Min, Byung-Moo | - |
dc.contributor.affiliatedAuthor | Yeo, In-Sung Luke | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN LAMININ | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MOTIF | - |
dc.subject.keywordAuthor | bone-implant interface | - |
dc.subject.keywordAuthor | DLTIDDSYWYRI motif | - |
dc.subject.keywordAuthor | initial osseointegration | - |
dc.subject.keywordAuthor | osteoblastic activity | - |
dc.subject.keywordAuthor | SLA titanium implant | - |
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