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Hepatoprotective effect of a novel lactic acid-fermented garlic extract functional food product against acute liver injury
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Kim, Ki Hoon | - |
dc.contributor.author | Jo, Jeong Hyun | - |
dc.contributor.author | Park, Joonghoon | - |
dc.contributor.author | Kwon, Yong Sam | - |
dc.contributor.author | Yang, Je Hoon | - |
dc.date.accessioned | 2023-10-30T02:02:28Z | - |
dc.date.available | 2023-10-30T02:02:28Z | - |
dc.date.created | 2020-06-26 | - |
dc.date.created | 2020-06-26 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | Food Science and Nutrition, Vol.8 No.2, pp.1012-1019 | - |
dc.identifier.issn | 2048-7177 | - |
dc.identifier.uri | https://hdl.handle.net/10371/196007 | - |
dc.description.abstract | Lactic acid-fermented garlic extract (LAFGE) has been shown to have hepatoprotective role in liver diseases. This study was conducted to evaluate the efficacy of a new LAFGE-based hepatoprotective functional food product (named D-18-007) formulated with other additive components, including l-arginine, l-ornithine, and the leaf extract of licorice and artichoke. In a rat model of D-galactosamine(GalN)/LPS-induced liver injury, the survival was significantly higher in animals treated with D-18-007 than in animals treated with LAFGE. The hepatic injury was alleviated by either LAFGE or D-18-007, but the overall effect was more significant in D-18-007, as shown by the necrosis, histology, and serum analyses. Also, the decrease in GalN/LPS-induced lipid peroxidation in the liver tissue was more significant in D-18-007 than LAFGE. The decrease in IL-6 protein in the liver was similar between LAFGE and D-18-007. Moreover, we compared the amount of the bile in normal animals and found that D-18-007 has better choleretic activity than LAFGE. Using this acute liver injury model, our results suggest that D-18-007 has an enhanced hepatoprotective effect in acute liver injury compared with LAFGE alone. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley and Sons Ltd | - |
dc.title | Hepatoprotective effect of a novel lactic acid-fermented garlic extract functional food product against acute liver injury | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/fsn3.1385 | - |
dc.citation.journaltitle | Food Science and Nutrition | - |
dc.identifier.wosid | 000505495900001 | - |
dc.identifier.scopusid | 2-s2.0-85077864923 | - |
dc.citation.endpage | 1019 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 1012 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Tae Min | - |
dc.contributor.affiliatedAuthor | Park, Joonghoon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ARTICHOKE LEAF EXTRACT | - |
dc.subject.keywordPlus | CYNARA-SCOLYMUS | - |
dc.subject.keywordPlus | ANTIMICROBIAL ACTIVITIES | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | HEPATIC-FAILURE | - |
dc.subject.keywordPlus | LICORICE | - |
dc.subject.keywordPlus | GALACTOSAMINE | - |
dc.subject.keywordPlus | ASPARTATE | - |
dc.subject.keywordAuthor | acute liver injury | - |
dc.subject.keywordAuthor | hepatoprotective functional food | - |
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