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Dissociation in Pharmacokinetic Attenuation Between Central Dopamine D2 Receptor Occupancy and Peripheral Blood Concentration of Antipsychotics: A Systematic Review
DC Field | Value | Language |
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dc.contributor.author | Kurose, Shin | - |
dc.contributor.author | Mimura, Yu | - |
dc.contributor.author | Uchida, Hiroyuki | - |
dc.contributor.author | Takahata, Keisuke | - |
dc.contributor.author | Kim, Euitae | - |
dc.contributor.author | Suzuki, Takefumi | - |
dc.contributor.author | Mimura, Masaru | - |
dc.contributor.author | Takeuchi, Hiroyoshi | - |
dc.date.accessioned | 2023-11-24T04:40:09Z | - |
dc.date.available | 2023-11-24T04:40:09Z | - |
dc.date.created | 2021-01-22 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | Journal of Clinical Psychiatry, Vol.81 No.5 | - |
dc.identifier.issn | 0160-6689 | - |
dc.identifier.uri | https://hdl.handle.net/10371/197529 | - |
dc.description.abstract | © Copyright 2020 Physicians Postgraduate Press, Inc.OBJECTIVE: The objective of this study was to examine the extent of possible dissociation in pharmacokinetic decay between central dopamine D₂ receptor occupancy with antipsychotics and their peripheral blood concentrations. DATA SOURCES: MEDLINE and Embase were searched using the following keywords: (positron emission tomography OR PET OR single-photon emission computed tomography OR SPECT) AND (dopamine OR D2) AND (receptor* OR occupanc*) AND antipsychotic*, with a limitation of English language (last search: December 14, 2019). STUDY SELECTION: The search identified 18 studies that met the following criteria: (1) including patients with schizophrenia spectrum disorders and/or healthy subjects, (2) using positron emission tomography or single-photon emission computed tomography, and (3) examining the time courses of D₂ occupancy with antipsychotics and their blood concentrations. DATA EXTRACTION: The ratios of D₂ occupancy reduction rate (%) from peak to blood concentration reduction rate (%) from peak (relative attenuation ratio) were calculated. RESULTS: Among the studies, oral risperidone, olanzapine, quetiapine, aripiprazole, ziprasidone, perospirone, haloperidol, sulpiride, and clozapine and long-acting injectable risperidone and haloperidol were included. Relative attenuation ratios were less than 1, indicating a slower central versus peripheral attenuation, across the time points for all antipsychotic types and doses with only a few exceptions. The ratio decreased in a dose-dependent as well as a peak D₂ occupancy-dependent fashion. It contrarily increased in a time-dependent manner. CONCLUSIONS: The findings indicate pharmacokinetic attenuation of antipsychotics was generally slower at the central versus the peripheral level and pose a critical challenge to the current dosing strategy that primarily relies on peripheral pharmacokinetics of antipsychotics. | - |
dc.language | 영어 | - |
dc.publisher | Physicians Postgraduate Press, Inc. | - |
dc.title | Dissociation in Pharmacokinetic Attenuation Between Central Dopamine D2 Receptor Occupancy and Peripheral Blood Concentration of Antipsychotics: A Systematic Review | - |
dc.type | Article | - |
dc.identifier.doi | 10.4088/JCP.19r13113 | - |
dc.citation.journaltitle | Journal of Clinical Psychiatry | - |
dc.identifier.wosid | 000616429100006 | - |
dc.identifier.scopusid | 2-s2.0-85088879747 | - |
dc.citation.number | 5 | - |
dc.citation.volume | 81 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Euitae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | LOW-DOSE TREATMENT | - |
dc.subject.keywordPlus | MAINTENANCE TREATMENT | - |
dc.subject.keywordPlus | TIME-COURSE | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | PLASMA PHARMACOKINETICS | - |
dc.subject.keywordPlus | QUETIAPINE FUMARATE | - |
dc.subject.keywordPlus | IMMEDIATE-RELEASE | - |
dc.subject.keywordPlus | EXTENDED-RELEASE | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
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