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Inter-spike mitochondrial Ca2+ release enhances high frequency synaptic transmission
DC Field | Value | Language |
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dc.contributor.author | Yang, Che Ho | - |
dc.contributor.author | Lee, Kyu-Hee | - |
dc.contributor.author | Ho, Won-Kyung | - |
dc.contributor.author | Lee, Suk-Ho | - |
dc.date.accessioned | 2023-12-11T00:49:41Z | - |
dc.date.available | 2023-12-11T00:49:41Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | Journal of Physiology, Vol.599 No.5, pp.1567-1594 | - |
dc.identifier.issn | 0022-3751 | - |
dc.identifier.uri | https://hdl.handle.net/10371/197804 | - |
dc.description.abstract | Key points Presynaptic mitochondria not only absorb but also release Ca2+ during high frequency stimulation (HFS) when presynaptic [Ca2+] is kept low (m) by high cytosolic Ca2+ buffer or strong plasma membrane calcium clearance mechanisms under physiological external [Ca2+]. Mitochondrial Ca2+ release (MCR) does not alter the global presynaptic Ca2+ transients. MCR during HFS enhances short-term facilitation and steady state excitatory postsynaptic currents by increasing vesicular release probability. The intra-train MCR may provide residual calcium at interspike intervals, and thus support high frequency neurotransmission at central glutamatergic synapses. Emerging evidence indicates that mitochondrial Ca2+ buffering contributes to local regulation of synaptic transmission. It is unknown, however, whether mitochondrial Ca2+ release (MCR) occurs during high frequency synaptic transmission. Confirming the previous notion that 2 mu m tetraphenylphosphonium (TPP+) is a specific inhibitor of the mitochondrial Na+/Ca2+ exchanger (mNCX), we studied the role of MCR via mNCX in short-term plasticity during high frequency stimulation (HFS) at the calyx of Held synapse of the rat. TPP+ reduced short-term facilitation (STF) and steady state excitatory postsynaptic currents during HFS at mature calyx synapses under physiological extracellular [Ca2+] ([Ca2+](o) = 1.2 mm), but not at immature calyx or at 2 mm [Ca2+](o). The inhibitory effects of TPP+ were stronger at synapses with morphologically complex calyces harbouring many swellings and at 32 degrees C than at simple calyx synapses and at room temperature. These effects of TPP+ on STF were well correlated with those on the presynaptic mitochondrial [Ca2+] build-up during HFS. Mitochondrial [Ca2+] during HFS was increased by TPP+ at mature calyces under 1.2 mm [Ca2+](o), and further enhanced at 32 degrees C, but not under 2 mm [Ca2+](o) or at immature calyces. The close correlation of the effects of TPP+ on mitochondrial [Ca2+] with those on STF suggests that mNCX contributes to STF at the calyx of Held synapses. The intra-train MCR enhanced vesicular release probability without altering global presynaptic [Ca2+]. Our results suggest that MCR during HFS elevates local [Ca2+] near synaptic sites at interspike intervals to enhance STF and to support stable synaptic transmission under physiological [Ca2+](o). | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Inter-spike mitochondrial Ca2+ release enhances high frequency synaptic transmission | - |
dc.type | Article | - |
dc.identifier.doi | 10.1113/JP280351 | - |
dc.citation.journaltitle | Journal of Physiology | - |
dc.identifier.wosid | 000590607300001 | - |
dc.identifier.scopusid | 2-s2.0-85096794283 | - |
dc.citation.endpage | 1594 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 1567 | - |
dc.citation.volume | 599 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Ho, Won-Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Suk-Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SHORT-TERM DEPRESSION | - |
dc.subject.keywordPlus | HIPPOCAMPAL MOSSY FIBER | - |
dc.subject.keywordPlus | POSTTETANIC POTENTIATION | - |
dc.subject.keywordPlus | PRESYNAPTIC MITOCHONDRIA | - |
dc.subject.keywordPlus | RAPID RECRUITMENT | - |
dc.subject.keywordPlus | RAT CALYX | - |
dc.subject.keywordPlus | VESICLES | - |
dc.subject.keywordPlus | FACILITATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | calyx of held | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | presynaptic | - |
dc.subject.keywordAuthor | residual calcium | - |
dc.subject.keywordAuthor | short& | - |
dc.subject.keywordAuthor | #8208 | - |
dc.subject.keywordAuthor | term facilitation | - |
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