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Association between telomere length and completed suicide observed in 71 suicide victims - Preliminary findings
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyeyoung | - |
dc.contributor.author | Cho, Sung Joon | - |
dc.contributor.author | Yoo, Seong Ho | - |
dc.contributor.author | Kim, Se Hyun | - |
dc.contributor.author | Ahn, Yong Min | - |
dc.date.accessioned | 2023-12-11T05:25:07Z | - |
dc.date.available | 2023-12-11T05:25:07Z | - |
dc.date.created | 2020-01-30 | - |
dc.date.created | 2020-01-30 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | Journal of Psychosomatic Research, Vol.120, pp.8-11 | - |
dc.identifier.issn | 0022-3999 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198230 | - |
dc.description.abstract | Objective: Telomere length has emerged as a cumulative marker for lifestyle, psychosocial stress, and cytotoxic environments. We aimed to examine the possible association between leukocyte telomere length (LTL) and completed suicide. Methods: This study included 71 suicide completers and 117 healthy controls for whom LTL was determined by the ratio of the telomere repeat copy number to the single-copy gene copy number (T/S ratio). We compared the LTL between the suicide completers and the healthy controls and estimated the odds ratio (OR) for suicide for each age group, applying a generalized estimating equation (GEE). Results: LTL was significantly shortened in the suicide completers as compared with the controls, overall subjects, or within-age categories (<= 29 and 30-49 years). Furthermore, a longer LTL was associated with significantly decreased odds of completed suicide for those aged 5 29 years and 30-49 years (OR = 0.11, 95% confidence interval [CI] 0.03-0.37, p < .001 for the <= 29-year age group; OR = 0.54, 95% CI 0.34-0.84, p = .006 for the 30- to 49-year age group). Conclusions: This study provides evidence regarding the relationship between shortened LTL and completed suicide, especially in those aged < 50 years. Future research should further assess potential confounders and examine underlying mechanisms. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Association between telomere length and completed suicide observed in 71 suicide victims - Preliminary findings | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jpsychores.2019.02.008 | - |
dc.citation.journaltitle | Journal of Psychosomatic Research | - |
dc.identifier.wosid | 000464627300002 | - |
dc.identifier.scopusid | 2-s2.0-85062345085 | - |
dc.citation.endpage | 11 | - |
dc.citation.startpage | 8 | - |
dc.citation.volume | 120 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yoo, Seong Ho | - |
dc.contributor.affiliatedAuthor | Ahn, Yong Min | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Leukocyte telomere length | - |
dc.subject.keywordAuthor | Suicide | - |
dc.subject.keywordAuthor | Suicide completers | - |
dc.subject.keywordAuthor | Suicide risk | - |
dc.subject.keywordAuthor | Telomere | - |
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