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CD4(hi)CD8(low) double-positive t cells are associated with graft rejection in a nonhuman primate model of islet transplantation
DC Field | Value | Language |
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dc.contributor.author | Choi, Yun Jung | - |
dc.contributor.author | Park, Hi-Jung | - |
dc.contributor.author | Park, Hye Jin | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.contributor.author | Lee, Jae-Il | - |
dc.date.accessioned | 2023-12-11T05:50:31Z | - |
dc.date.available | 2023-12-11T05:50:31Z | - |
dc.date.created | 2019-05-24 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.citation | Journal of Immunology Research, Vol.2018, p. 3861079 | - |
dc.identifier.issn | 2314-8861 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198322 | - |
dc.description.abstract | Peripheral CD4/CD8 double-positive (DP) T cells are associated with autoimmune disorders, cancer, and viral infection. However, the relationship between organ transplantation and DP T cells is unclear. Here, we examined the functional characteristics of peripheral DP T cells and analyzed their significance with respect to islet graft rejection in a nonhuman primate model of islet transplantation. DP T cells were functionally equivalent to conventional CD4 and CD8 T cells in terms of helper and cytotoxic activity, respectively. DP T cells expressed high levels of CXCR5 and PD-1 and secreted IFN-gamma, IL-4, and IL-21 in amounts equivalent to those secreted by CD4 or CD8 T cells; also, they produced large amounts of granzyme B and perform. In addition, under steady-state conditions, DP T cells expressed eomesodermin (Eomes) and promyelocytic leukemia zinc finger (PLZF) proteins, both of which act as transcription factors in innate/memory-like T cells. The number of peripheral DP T cells in the islet transplantation model was high in the group that experienced graft rejection; this was not the case in the long-term survival group. Interestingly, numbers of effector memory T cells (TEM) within the DP T cell population increased significantly during islet graft rejection, as did those of TEM within the cytotoxic CD8 T cells. Furthermore, the most conspicuous of which was the increase of CD4(hi)CD8(low )T cell subpopulation at that point. Taken together, the data suggest that peripheral DP T cells showing an innate/memory-like phenotype have both helper and cytotoxic activity in vitro and that they may act as a novel biomarker for graft rejection after islet transplantation. | - |
dc.language | 영어 | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.title | CD4(hi)CD8(low) double-positive t cells are associated with graft rejection in a nonhuman primate model of islet transplantation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2018/3861079 | - |
dc.citation.journaltitle | Journal of Immunology Research | - |
dc.identifier.wosid | 000446947200001 | - |
dc.identifier.scopusid | 2-s2.0-85056289554 | - |
dc.citation.startpage | 3861079 | - |
dc.citation.volume | 2018 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Jung, Kyeong Cheon | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Il | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NATURAL TH1 CELLS | - |
dc.subject.keywordPlus | TEC KINASE ITK | - |
dc.subject.keywordPlus | CYNOMOLGUS MONKEYS | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | GAMMA-DELTA | - |
dc.subject.keywordPlus | SYSTEMIC-SCLEROSIS | - |
dc.subject.keywordPlus | MEMORY CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | CD4 | - |
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