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Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)-Modified Live Vaccines Reduce Seminal Shedding of Type 1 PRRSV but not Type 2 PRRSV in Infected Boars
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, C. | - |
dc.contributor.author | Kim, T. | - |
dc.contributor.author | Choi, K. | - |
dc.contributor.author | Jeong, J. | - |
dc.contributor.author | Kang, I. | - |
dc.contributor.author | Park, S. -J. | - |
dc.contributor.author | Chae, C. | - |
dc.date.accessioned | 2023-12-11T06:31:10Z | - |
dc.date.available | 2023-12-11T06:31:10Z | - |
dc.date.created | 2018-07-24 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | Transboundary and Emerging Diseases, Vol.64 No.1, pp.194-203 | - |
dc.identifier.issn | 1865-1674 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198363 | - |
dc.description.abstract | The objective of this study was to compare the effects of two commercial type 1 porcine reproductive and respiratory syndrome virus (PRRSV)-modified live vaccines on type 1 and type 2 PRRSV shedding in the semen of experimentally infected boars. Upon challenge with PRRSV, unvaccinated boars exhibited an increase in daily rectal temperature (39.4-39.7 degrees C). Vaccination of boars with type 1 PRRSV significantly reduced the amount of type 1 PRRSV load in blood and semen after challenge with type 1 PRRSV, but barely reduced the amount of type 2 PRRSV load in blood and semen after the type 2 PRRSV challenge. There were no significant differences in the reduction of viremia and seminal shedding of type 1 and type 2 PRRSV between the two commercial vaccines. The seminal shedding of PRRSV is independent of viremia. The reduction of type 1 PRRSV seminal shedding coincided with the appearance of type 1 PRRSV-specific interferon-gamma secreting cells (IFN-gamma-SC) in vaccinated type 1 PRRSV-challenged boars. The frequencies of type 1 PRRSV-specific IFN-gamma-SC induced by type 1 PRRSV vaccine are relatively high compared to type 2 PRRSV-specific IFN-gamma-SC induced by the same vaccine which may explain why type 1 PRRSV vaccine is more effective in reducing seminal shedding of type 1 PRRSV when compared to type 2 PRRSV in vaccinated challenged boars. These results provide clinical information on how to reduce seminal shedding of type 1 PRRSV in boars using type 1 PRRSV-modified live vaccine. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell-Wiss.-Verl | - |
dc.title | Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)-Modified Live Vaccines Reduce Seminal Shedding of Type 1 PRRSV but not Type 2 PRRSV in Infected Boars | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/tbed.12361 | - |
dc.citation.journaltitle | Transboundary and Emerging Diseases | - |
dc.identifier.wosid | 000392275600020 | - |
dc.identifier.scopusid | 2-s2.0-84927946498 | - |
dc.citation.endpage | 203 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 194 | - |
dc.citation.volume | 64 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chae, C. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POLYMERASE-CHAIN-REACTION | - |
dc.subject.keywordPlus | REAL-TIME PCR | - |
dc.subject.keywordPlus | NORTH-AMERICAN | - |
dc.subject.keywordPlus | EUROPEAN-LIKE | - |
dc.subject.keywordPlus | BOVINE SEMEN | - |
dc.subject.keywordPlus | ADULT BOARS | - |
dc.subject.keywordPlus | PIGS | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | TRANSMISSION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordAuthor | boar | - |
dc.subject.keywordAuthor | cross-protection | - |
dc.subject.keywordAuthor | porcine reproductive and respiratory syndrome virus | - |
dc.subject.keywordAuthor | semen | - |
dc.subject.keywordAuthor | vaccine | - |
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