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α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption : α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption
DC Field | Value | Language |
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dc.contributor.author | Kim, Ha-Neui | - |
dc.contributor.author | Lee, Jong-Ho | - |
dc.contributor.author | Jin, Won Jong | - |
dc.contributor.author | Lee, Zang Hee | - |
dc.date.accessioned | 2023-12-11T07:45:01Z | - |
dc.date.available | 2023-12-11T07:45:01Z | - |
dc.date.created | 2020-07-02 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | 대한골대사학회지, Vol.19 No.2, pp.111-120 | - |
dc.identifier.issn | 2287-6375 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198627 | - |
dc.description.abstract | Objective: Osteoclasts are bone-resorbing multinucleated cells derived from the monocyte/macrophage lineage during normal and pathological bone turnover. Recently, several studies revealed that alpha-tocopheryl succinate (αTP-suc)have demonstrated potent anti-cancer activities in vitro and in vivo. However, the effects of αTP-suc on osteoclast formation and bone resorption remain unknown. Thus, in this study, we examined the effects of αTP-suc on osteoclast differentiation and bone resorbing activity in inflammatory bone loss model. Methods: Osteoclast differentiation assay was performed by cocultures of mouse bone marrow cells and calvarial osteoblasts in culture media including interleukin-1 (IL-1). Osteoclasts were stained for tartrate-resistant acid phosphatase (TRAP). The level of receptor activator of nuclear factor-kappaB ligand (RANKL) mRNA was determined by reverse transcriptase-polymerase chain reaction (RT-PCR). ICR mice were administered an intraperitoneal injections of αTP-suc or dimethyl sulfoxide (DMSO) 1 day before the implantation of a freeze-dried collagen sponge loaded with phosphate-buffered saline (PBS) or IL-1 over the calvariae and every other day for 7 days. The whole calvariae were obtained and analyzed by micro-computed tomography (CT) scanning, and stained for TRAP. Results: αTP-suc inhibits osteoclast formation in cocultures stimulated by IL-1 and decreased the level of expression of RANKL mRNA in osteoblasts. In addition, administered intraperitoneal injections of αTP-suc prevented IL-1-mediated osteoclast formation and bone loss in vivo. Conclusion: Our findings suggest that αTP-suc may have therapeutic value for treating and preventing bone-resorptive diseases, such as osteoporosis. | - |
dc.language | 영어 | - |
dc.publisher | 대한골대사학회 | - |
dc.title | α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption | - |
dc.title.alternative | α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption | - |
dc.type | Article | - |
dc.identifier.doi | 10.11005/jbm.2012.19.2.111 | - |
dc.citation.journaltitle | 대한골대사학회지 | - |
dc.citation.endpage | 120 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 111 | - |
dc.citation.volume | 19 | - |
dc.identifier.kciid | ART001711596 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Zang Hee | - |
dc.type.docType | Article | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | Alpha-tocopheryl succinate, Interleukin-1, Osteoclast, Osteoporosis, RANKL | - |
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