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White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimers disease continuum
DC Field | Value | Language |
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dc.contributor.author | Hirschfeld, Lauren R. | - |
dc.contributor.author | Deardorff, Rachael | - |
dc.contributor.author | Chumin, Evgeny J. | - |
dc.contributor.author | Wu, Yu-Chien | - |
dc.contributor.author | McDonald, Brenna C. | - |
dc.contributor.author | Cao, Sha | - |
dc.contributor.author | Risacher, Shannon L. | - |
dc.contributor.author | Yi, Dahyun | - |
dc.contributor.author | Byun, Min Soo | - |
dc.contributor.author | Lee, Jun-Young | - |
dc.contributor.author | Kim, Yu Kyeong | - |
dc.contributor.author | Kang, Koung Mi | - |
dc.contributor.author | Sohn, Chul-Ho | - |
dc.contributor.author | Nho, Kwangsik | - |
dc.contributor.author | Saykin, Andrew J. | - |
dc.contributor.author | Lee, Dong Young | - |
dc.date.accessioned | 2023-12-18T01:25:59Z | - |
dc.date.available | 2023-12-18T10:26:29Z | - |
dc.date.issued | 2023-12-16 | - |
dc.identifier.citation | Alzheimer's Research & Therapy, Vol.15(1):218 | ko_KR |
dc.identifier.issn | 1758-9193 | - |
dc.identifier.uri | https://hdl.handle.net/10371/198719 | - |
dc.description.abstract | Background
White matter (WM) microstructural changes in the hippocampal cingulum bundle (CBH) in Alzheimers disease (AD) have been described in cohorts of largely European ancestry but are lacking in other populations. Methods We assessed the relationship between CBH WM integrity and cognition or amyloid burden in 505 Korean older adults aged ≥ 55 years, including 276 cognitively normal older adults (CN), 142 with mild cognitive impairment (MCI), and 87 AD patients, recruited as part of the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimers disease (KBASE) at Seoul National University. Results Compared to CN, AD and MCI subjects showed significantly higher RD, MD, and AxD values (all p-values < 0.001) and significantly lower FA values (left p ≤ 0.002, right p ≤ 0.015) after Bonferroni adjustment for multiple comparisons. Most tests of cognition and mood (p < 0.001) as well as higher medial temporal amyloid burden (p < 0.001) were associated with poorer WM integrity in the CBH after Bonferroni adjustment. Conclusion These findings are consistent with patterns of WM microstructural damage previously reported in non-Hispanic White (NHW) MCI/AD cohorts, reinforcing existing evidence from predominantly NHW cohort studies. | ko_KR |
dc.description.sponsorship | This publication receives support from multiple NIH grants (P30 AG010133, P30 AG072976, R01 AG019771, R01 AG061788, R01 AG057739, U19 AG024904, R01 LM013463, R01 LM012535, U01AG61356, R01 AG068193, U01 AG068057, U01 AG072177, U19 AG074879, T32 AG071444, and F31 AG074700), a grant from the Ministry of Science and ICT, Republic of Korea (NRF-2014M3C7A1046042), a grant from the Ministry of Health & Welfare, Republic of Korea (HI18C0630 and HI19C0149), a grant from the Seoul National University Hospital, Republic of Korea (No. 3020200030) | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Cingulum bundle of the hippocampus | - |
dc.subject | White matter | - |
dc.subject | Alzheimer’s disease | - |
dc.subject | Mild cognitive impairment | - |
dc.subject | Cognition | - |
dc.title | White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimers disease continuum | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s13195-023-01369-5 | ko_KR |
dc.citation.journaltitle | Alzheimer's Research & Therapy | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2023-12-17T04:08:53Z | - |
dc.citation.endpage | 11 | ko_KR |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 1 | ko_KR |
dc.citation.volume | 15 | ko_KR |
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