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Independent association of thigh muscle fat density with vascular events in Korean adults
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- Authors
- Issue Date
- 2024-01-28
- Publisher
- BMC
- Citation
- Cardiovascular Diabetology, Vol.23, no.44
- Keywords
- Myosteatosis ; Ectopic fat ; Coronary artery disease ; Cardiovascular disease
- Abstract
- Background
We aimed to explore the associations between thigh muscle fat density and vascular events.
Methods
A total of 3,595 adults (mean age, 57.2 years; women, 1,715 [47.7%]) without baseline cardiovascular events from the Korean Atherosclerosis Study-2 were included. Muscle and fat area at the mid-thigh level were measured by computed tomography (CT) using the following Hounsfield Unit range: 0–30 for low density muscle (LDM); 31–100 for normal density muscle (NDM); and − 250 to − 50 for fat.
Results
During a median follow-up period of 11.8 (4.3–13.9) years, vascular events occurred in 11.6% of men and 5.9% of women. Individuals with vascular events had a larger LDM area (men: 48.8 ± 15.5 cm2 vs. 44.6 ± 14.5 cm2; women: 39.4 ± 13.2 cm2 vs. 35.0 ± 11.8 cm2, both P < 0.001) compared with those who did not have vascular events during the follow-up of at least 5 years. The LDM/NDM ratio was also independently associated with vascular events after adjusting for cardiometabolic risk factors. Moreover, the LDM/NDM ratio improved the prognostic value for vascular events when added to conventional risk factors.
Conclusions
The current study suggests that a higher thigh muscle fat infiltration is associated with an increased risk of developing vascular events among Korean adults.
- ISSN
- 1475-2840
- Language
- English
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