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Development of finely tuned liposome nanoplatform for macrophage depletion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Tae Hyeon | - |
dc.contributor.author | Yoo, Ran Ji | - |
dc.contributor.author | Park, Ji Young | - |
dc.contributor.author | Kim, Ji Yoon | - |
dc.contributor.author | Ann, Young Chan | - |
dc.contributor.author | Park, Jeongbin | - |
dc.contributor.author | Kim, Jin Sil | - |
dc.contributor.author | Kim, Kyuwan | - |
dc.contributor.author | Shin, Yu Jin | - |
dc.contributor.author | Lee, Yong Jin | - |
dc.contributor.author | Lee, Kyo Chul | - |
dc.contributor.author | Park, Jisu | - |
dc.contributor.author | Chung, Hyewon | - |
dc.contributor.author | Seok, Seung Hyeok | - |
dc.contributor.author | Im, Hyung-Jun | - |
dc.contributor.author | Lee, Yun-Sang | - |
dc.date.accessioned | 2024-03-04T07:57:30Z | - |
dc.date.available | 2024-03-04T16:57:55Z | - |
dc.date.issued | 2024-02-29 | - |
dc.identifier.citation | Journal of Nanobiotechnology, Vol.22 no.83 | ko_KR |
dc.identifier.issn | 1477-3155 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199052 | - |
dc.description.abstract | Background
Immunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously reported liposomal formulation-based drugs (Clodrosome® and m-Clodrosome®) are limited by their inconsistent size and therapeutic efficacy. Thus, we aimed to achieve consistent therapeutic effects by effectively depleting macrophages with uniform-sized liposomes. Results We developed four types of click chemistry-based liposome nanoplatforms that were uniformly sized and encapsulated with clodronate, for effective macrophage depletion, followed by conjugation with Man-N3 and radiolabeling. Functionalization with Man-N3 improves the specific targeting of M2 macrophages, and radioisotope labeling enables in vivo imaging of the liposome nanoplatforms. The functionalized liposome nanoplatforms are stable under physiological conditions. The difference in the biodistribution of the four liposome nanoplatforms in vivo were recorded using positron emission tomography imaging. Among the four platforms, the clodronate-encapsulated mannosylated liposome effectively depleted M2 macrophages in the normal liver and tumor microenvironment ex vivo compared to that by Clodrosome® and m-Clodrosome®. Conclusion The newly-developed liposome nanoplatform, with finely tuned size control, high in vivo stability, and excellent ex vivo M2 macrophage targeting and depletion effects, is a promising macrophage-depleting agent. | ko_KR |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2021R1C1C2004706 and 2021R1A2C3009427) and the Ministry of Health and Welfare (No. HN22C0644). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Liposome | - |
dc.subject | Macrophage | - |
dc.subject | Clodronate | - |
dc.subject | Molecular imaging | - |
dc.subject | Click chemistry | - |
dc.title | Development of finely tuned liposome nanoplatform for macrophage depletion | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s12951-024-02325-7 | ko_KR |
dc.citation.journaltitle | Journal of Nanobiotechnology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2024-03-03T04:10:03Z | - |
dc.citation.endpage | 13 | ko_KR |
dc.citation.number | 83 | ko_KR |
dc.citation.startpage | 1 | ko_KR |
dc.citation.volume | 22 | ko_KR |
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