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ER remodeling via lipid metabolism
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Wonyul | - |
dc.contributor.author | Haucke, Volker | - |
dc.date.accessioned | 2024-04-22T05:14:30Z | - |
dc.date.available | 2024-04-22T05:14:30Z | - |
dc.date.created | 2024-04-22 | - |
dc.date.created | 2024-04-22 | - |
dc.date.created | 2024-04-22 | - |
dc.date.created | 2024-04-22 | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Trends in Cell Biology | - |
dc.identifier.issn | 0962-8924 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199269 | - |
dc.description.abstract | Unlike most other organelles found in multiple copies, the endoplasmic reticulum (ER) is a unique singular organelle within eukaryotic cells. Despite its continuous membrane structure, encompassing more than half of the cellular endomembrane system, the ER is subdivided into specialized sub-compartments, including morphological, membrane contact site (MCS), and de novo organelle biogenesis domains. In this review, we discuss recent emerging evidence indicating that, in response to nutrient stress, cells undergo a reorganization of these sub-compartmental ER domains through two main mechanisms: non-destructive remodeling of morphological ER domains via regulation of MCS and organelle hitchhiking, and destructive remodeling of specialized domains by ER-phagy. We further highlight and propose a critical role of membrane lipid metabolism in this ER remodeling during starvation. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier Ltd | - |
dc.title | ER remodeling via lipid metabolism | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.tcb.2024.01.011 | - |
dc.citation.journaltitle | Trends in Cell Biology | - |
dc.identifier.scopusid | 2-s2.0-85186107275 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Jang, Wonyul | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | endoplasmic reticulum | - |
dc.subject.keywordAuthor | hitchhiking | - |
dc.subject.keywordAuthor | lipids | - |
dc.subject.keywordAuthor | membrane contact sites | - |
dc.subject.keywordAuthor | membrane remodeling | - |
dc.subject.keywordAuthor | metabolism | - |
dc.subject.keywordAuthor | nutrient stress | - |
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