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Enhancement of S(+)-zaltoprofen oral bioavailability using nanostructured lipid carrier system
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Thi Mai Anh Pham | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Na, Young-Guk | - |
dc.contributor.author | Jin, Minki | - |
dc.contributor.author | Jung, Minwoo | - |
dc.contributor.author | Kim, Ha-Eun | - |
dc.contributor.author | Yoo, Hyelim | - |
dc.contributor.author | Won, Jong-Hee | - |
dc.contributor.author | Lee, Jae-Young | - |
dc.contributor.author | Baek, Jong-Suep | - |
dc.contributor.author | Han, Su-Cheol | - |
dc.contributor.author | Lee, Hong-Ki | - |
dc.contributor.author | Cho, Cheong-Weon | - |
dc.date.accessioned | 2024-04-26T00:23:57Z | - |
dc.date.available | 2024-04-26T00:23:57Z | - |
dc.date.created | 2024-04-25 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH, Vol.45 No.11, pp.822-835 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199462 | - |
dc.description.abstract | Zaltoprofen is a nonsteroidal anti-inflammatory drug with poor oral bioavailability. S(+)-zaltoprofen (SZPF)-loaded nanostructured lipid carriers (NLCs) were prepared to enhance oral bioavailability. SZPF-loaded NLCs (NLC-SZPF) were prepared using the hot-melting homogenization method and optimized using the Box-Behnken design. The characterization of optimized NLC-SZPF, in vitro release, cytotoxicity, cellular uptake, ex vivo permeability, and pharmacokinetic parameters were evaluated to confirm the advantages of NLC formulation. NLC-SZPF with a diameter of 105.5 +/- 1.2 nm had a high encapsulation efficiency of 99.84 +/- 0.01%. NLC-SZPF showed a sustained-release profile, high biocompatibility, and high permeability across the intestinal tract. The relative bioavailability of NLC-SZPF was 431.3% compared with that of SZPF after oral administration to experimental rats. NLC-SZPF was successfully optimized using experimental designs to enhance the oral bioavailability of SZPF. Hence, NLC-SZPF could be a promising approach to overcome the poor oral bioavailability of SZPF. | - |
dc.language | 영어 | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Enhancement of S(+)-zaltoprofen oral bioavailability using nanostructured lipid carrier system | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12272-022-01413-2 | - |
dc.citation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.identifier.wosid | 000875511400002 | - |
dc.identifier.scopusid | 2-s2.0-85140836771 | - |
dc.citation.endpage | 835 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 822 | - |
dc.citation.volume | 45 | - |
dc.identifier.kciid | ART002897742 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Young | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NANOPARTICLES SLN | - |
dc.subject.keywordPlus | DELIVERY-SYSTEM | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ZALTOPROFEN | - |
dc.subject.keywordPlus | NLC | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | DISPOSITION | - |
dc.subject.keywordAuthor | Nanostructured lipid carrier | - |
dc.subject.keywordAuthor | S(+)-zaltoprofen | - |
dc.subject.keywordAuthor | Box-Behnken design | - |
dc.subject.keywordAuthor | Optimization | - |
dc.subject.keywordAuthor | Bioavailability | - |
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