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Hyaluronic acid/doxorubicin nanoassembly-releasing microspheres for the transarterial chemoembolization of a liver tumor
DC Field | Value | Language |
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dc.contributor.author | Lee, Song Yi | - |
dc.contributor.author | Choi, Jin Woo | - |
dc.contributor.author | Lee, Jae-Young | - |
dc.contributor.author | Kim, Dae-Duk | - |
dc.contributor.author | Kim, Hyo-Cheol | - |
dc.contributor.author | Cho, Hyun-Jong | - |
dc.date.accessioned | 2024-04-26T00:25:50Z | - |
dc.date.available | 2024-04-26T00:25:50Z | - |
dc.date.created | 2019-06-20 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | Drug Delivery, Vol.25 No.1, pp.1472-1483 | - |
dc.identifier.issn | 1071-7544 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199496 | - |
dc.description.abstract | Doxorubicin (DOX)-loaded, hyaluronic acid-ceramide (HACE) nanoassembly-releasing poly(lactic-co-glycolic acid) (PLGA) microspheres (MSs) were developed for transarterial chemoembolization (TACE) therapy of liver cancer. DOX/HACE MSs with a mean diameter of 27m and a spherical shape were prepared based on the modified emulsification method. Their in vitro biodegradability in artificial biological fluids was observed. A more sustained drug release pattern was observed from DOX/HACE MS than from DOX MS at pH 7.4. The cellular internalization efficiency of DOX of the DOX/HACE MS group was higher than that of the DOX MS group in liver cancer cells (HepG2 and McA-RH7777 cells), mainly due to CD44 receptor-mediated endocytosis of the released DOX/HACE nanoassembly. In both HepG2 and McA-RH7777 cells, the antiproliferation and apoptotic potentials of the DOX/HACE MS were significantly higher than those of the DOX MS (p<.05). Notably, in the McA-RH7777 tumor-implanted rat models, a better tumor growth suppression, a lower tumor viable portion, and a higher incidence of apoptosis were presented in the DOX/HACE MS group than in the DOX MS group after intra-arterial (IA) administration. DOX/HACE-based nanoassembly release from the DOX/HACE MS seems to elevate the cellular accumulation of DOX and its anticancer activities. The developed DOX/HACE MS can be used as a drug-loaded HA nanoassembly-releasing MS system for TACE therapy of liver cancer. | - |
dc.language | 영어 | - |
dc.publisher | Taylor & Francis | - |
dc.title | Hyaluronic acid/doxorubicin nanoassembly-releasing microspheres for the transarterial chemoembolization of a liver tumor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/10717544.2018.1480673 | - |
dc.citation.journaltitle | Drug Delivery | - |
dc.identifier.wosid | 000435676500001 | - |
dc.identifier.scopusid | 2-s2.0-85053473388 | - |
dc.citation.endpage | 1483 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 1472 | - |
dc.citation.volume | 25 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Young | - |
dc.contributor.affiliatedAuthor | Kim, Dae-Duk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SELF-ASSEMBLED NANOPARTICLES | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | TARGETED DELIVERY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CARBOXYMETHYL CHITOSAN | - |
dc.subject.keywordPlus | ELUTING BEAD | - |
dc.subject.keywordPlus | EMBOLIZATION | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Doxorubicin | - |
dc.subject.keywordAuthor | liver tumor | - |
dc.subject.keywordAuthor | microsphere | - |
dc.subject.keywordAuthor | nanoassembly | - |
dc.subject.keywordAuthor | transarterial chemoembolization | - |
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