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Iodinated hyaluronic acid oligomer-based nanoassemblies for tumor-targeted drug delivery and cancer imaging
DC Field | Value | Language |
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dc.contributor.author | Lee, Jae-Young | - |
dc.contributor.author | Chung, Suk-Jae | - |
dc.contributor.author | Cho, Hyun-Jong | - |
dc.contributor.author | Kim, Dae-Duk | - |
dc.date.accessioned | 2024-04-26T00:26:56Z | - |
dc.date.available | 2024-04-26T00:26:56Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | Biomaterials, Vol.85, pp.218-231 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199514 | - |
dc.description.abstract | Nano-sized self-assemblies based on amphiphilic iodinated hyaluronic acid (HA) were developed for use in cancer diagnosis and therapy. 2,3,5-Triiodobenzoic acid (TIBA) was conjugated to an HA oligomer as a computed tomography (CT) imaging modality and a hydrophobic residue. Nanoassembly based on HA-TIBA was fabricated for tumor-targeted delivery of doxorubicin (DOX). Cellular uptake of DOX from nanoassembly, compared to a DOX solution group, was enhanced via an HA-CD44 receptor interaction, and subsequently, the in vitro antitumor efficacy of DOX-loaded nanoassembly was improved in SCC7 (CD44 receptor positive squamous cell carcinoma) cells. Cy5.5, a near-infrared fluorescence (NIRF) dye, was attached to the HA-TIBA conjugate and the in vivo tumor targetability of HA-TIBA nanoassembly, which is based on the interaction between HA and CD44 receptor, was demonstrated in a NIRF imaging study using an SCC7 tumor-xenografted mouse model. Tumor targeting and cancer diagnosis with HA-TIBA nanoassembly were verified in a CT imaging study using the SCC7 tumor-xenografted mouse model. In addition to efficient cancer diagnosis using NIRF and CT imaging modalities, improved antitumor efficacies were shown. HA and TIBA can be used to produce HA-TIBA nanoassembly that may be a promising theranostic nanosystem for cancers that express the CD44 receptor. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Iodinated hyaluronic acid oligomer-based nanoassemblies for tumor-targeted drug delivery and cancer imaging | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2016.01.060 | - |
dc.citation.journaltitle | Biomaterials | - |
dc.identifier.wosid | 000371841400018 | - |
dc.identifier.scopusid | 2-s2.0-84958162936 | - |
dc.citation.endpage | 231 | - |
dc.citation.startpage | 218 | - |
dc.citation.volume | 85 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Young | - |
dc.contributor.affiliatedAuthor | Chung, Suk-Jae | - |
dc.contributor.affiliatedAuthor | Kim, Dae-Duk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SELF-ASSEMBLED NANOPARTICLES | - |
dc.subject.keywordPlus | THERANOSTIC NANOPARTICLES | - |
dc.subject.keywordPlus | POLYMERIC NANOPARTICLES | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | CD44 | - |
dc.subject.keywordPlus | NANOTECHNOLOGY | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | In vivo imaging | - |
dc.subject.keywordAuthor | Nanoassemblies | - |
dc.subject.keywordAuthor | Triiodobenzoic acid | - |
dc.subject.keywordAuthor | Tumor-targeted therapy | - |
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