Publications
Detailed Information
Selenoacyclovir and selenoganciclovir: Discovery of a new template for antiviral agents
Cited 51 time in
Web of Science
Cited 53 time in Scopus
- Authors
- Issue Date
- 2015-11
- Publisher
- American Chemical Society
- Citation
- Journal of Medicinal Chemistry, Vol.58 No.21, pp.8734-8738
- Abstract
- On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.
- ISSN
- 0022-2623
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.