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Phenylboronic acid-decorated chondroitin sulfate A-based theranostic nanoparticles for enhanced tumor targeting and penetration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae-Young | - |
dc.contributor.author | Chung, Suk-Jae | - |
dc.contributor.author | Cho, Hyun-Jong | - |
dc.contributor.author | Kim, Dae-Duk | - |
dc.date.accessioned | 2024-04-26T00:27:30Z | - |
dc.date.available | 2024-04-26T00:27:30Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | Advanced Functional Materials, Vol.25 No.24, pp.3705-3717 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://hdl.handle.net/10371/199524 | - |
dc.description.abstract | Phenylboronic acid-functionalized chondroitin sulfate A (CSA)-deoxycholic-acid (DOCA)-based nanoparticles (NPs) are prepared for tumor targeting and penetration. (3-Aminomethylphenyl)boronic acid (AMPB) is conjugated to CSA-DOCA conjugate via amide bond formation, and its successful synthesis is confirmed using proton nuclear magnetic resonance spectroscopy (H-1-NMR). Doxorubicin (DOX)-loaded CSA-DOCA-AMPB NPs with a mean diameter of similar to 200 nm, a narrow size distribution, negative zeta potential, and spherical morphology are prepared. DOX release from NPs is enhanced at acidic pH compared to physiological pH. CSA-DOCA-AMPB NPs exhibit improved cellular uptake in A549 (human lung adenocarcinoma) cells and penetration into A549 multicellular spheroids compared to CSA-DOCA NPs as evidenced by confocal laser scanning microscopy and flow cytometry. In vivo tumor targeting and penetrating by CSA-DOCA-AMPB NPs, based on both CSA-CD44 receptor and boronic acid-sialic acid interactions, is revealed using near-infrared fluorescence (NIRF) imaging. Penetration of NPs to the core of the tumor mass is observed in an A549 tumor xenografted mouse model and verified by three-dimensional NIRF imaging. Multiple intravenous injections of DOX-loaded CSA-DOCA-AMPB NPs efficiently inhibit the growth of A549 tumor in the xenografted mouse model and increase apoptosis. These boronic acid-rich NPs are promising candidates for cancer therapy and imaging. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Phenylboronic acid-decorated chondroitin sulfate A-based theranostic nanoparticles for enhanced tumor targeting and penetration | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/adfm.201500680 | - |
dc.citation.journaltitle | Advanced Functional Materials | - |
dc.identifier.wosid | 000356822200010 | - |
dc.identifier.scopusid | 2-s2.0-85027945126 | - |
dc.citation.endpage | 3717 | - |
dc.citation.number | 24 | - |
dc.citation.startpage | 3705 | - |
dc.citation.volume | 25 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Young | - |
dc.contributor.affiliatedAuthor | Chung, Suk-Jae | - |
dc.contributor.affiliatedAuthor | Kim, Dae-Duk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SELF-ASSEMBLED NANOPARTICLES | - |
dc.subject.keywordPlus | DOXORUBICIN DELIVERY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | SOLID TUMORS | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | COPOLYMERS | - |
dc.subject.keywordPlus | PRESSURE | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | chondroitin sulfate A | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | penetration | - |
dc.subject.keywordAuthor | phenylboronic acid | - |
dc.subject.keywordAuthor | targeting | - |
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