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Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae-Young | - |
dc.contributor.author | Kim, Jung Sun | - |
dc.contributor.author | Cho, Hyun-Jong | - |
dc.contributor.author | Kim, Dae-Duk | - |
dc.date.accessioned | 2024-04-26T00:28:03Z | - |
dc.date.available | 2024-04-26T00:28:03Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | International journal of nanomedicine, Vol.9 No.1, pp.2803-2813 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199534 | - |
dc.description.abstract | Poly(styrene)-b-poly(DL-lactide) (PS-PDLLA) copolymer-based nanoparticles (NPs) of a narrow size distribution, negative zeta potential, and spherical shape were fabricated for the delivery of docetaxel (DCT). The particle size was consistently maintained in serum for 24 hours and a sustained drug release pattern was observed for 10 days in the tested formulations. The cytotoxicity of the developed blank NPs was negligible in prostate cancer (PC-3) cells. Cellular uptake and distribution of the constructed NPs containing a hydrophobic fluorescent dye was monitored by confocal laser scanning microscopy (CLSM) for 24 hours. Anti-tumor efficacy of the PS-PDLLA/DCT NPs in PC-3 cells was significantly more potent than that of the group treated with commercially available DCT, Taxotere((R)) (P < 0.05). Blood biochemistry tests showed that no serious toxicity was observed with the blank NPs in the liver and kidney. In a pharmacokinetic study of DCT in rats, in vivo clearance of PS-PDLLA/DCT NPs decreased while the half-life in blood increased compared to the Taxotere-treated group (P < 0.05). The PS-PDLLA NPs are expected to be a biocompatible and efficient nano-delivery system for anticancer drugs. | - |
dc.language | 영어 | - |
dc.publisher | Dove Medical Press Ltd | - |
dc.title | Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/IJN.S62806 | - |
dc.citation.journaltitle | International journal of nanomedicine | - |
dc.identifier.wosid | 000337702000001 | - |
dc.identifier.scopusid | 2-s2.0-84901953410 | - |
dc.citation.endpage | 2813 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 2803 | - |
dc.citation.volume | 9 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Young | - |
dc.contributor.affiliatedAuthor | Kim, Dae-Duk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SELF-ASSEMBLED NANOPARTICLES | - |
dc.subject.keywordPlus | POLYSTYRENE NANOPARTICLES | - |
dc.subject.keywordPlus | THERANOSTIC LIPOSOMES | - |
dc.subject.keywordPlus | TARGETED DELIVERY | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | CO-DELIVERY | - |
dc.subject.keywordPlus | DOCETAXEL | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | SIRNA | - |
dc.subject.keywordAuthor | docetaxel | - |
dc.subject.keywordAuthor | prolonged blood circulation | - |
dc.subject.keywordAuthor | prostate cancer | - |
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