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Limited Positive Predictive Value of β-D-Glucan in Hematologic Patients Receiving Antimold Prophylaxis : Limited Positive Predictive Value of beta-D-Glucan in Hematologic Patients Receiving Antimold Prophylaxis
DC Field | Value | Language |
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dc.contributor.author | Chang, Euijin | - |
dc.contributor.author | Kim, Taek Soo | - |
dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Jun, Kang Il | - |
dc.contributor.author | Shin, Dongyeop | - |
dc.contributor.author | Koh, Youngil | - |
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Nam-Joong | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Kim, Inho | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.date.accessioned | 2024-04-26T01:01:51Z | - |
dc.date.available | 2024-04-26T01:01:51Z | - |
dc.date.created | 2020-05-22 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | Open Forum Infectious Diseases, Vol.7 No.3, p. ofaa048 | - |
dc.identifier.issn | 2328-8957 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199628 | - |
dc.description.abstract | Background. Diagnostic value of beta-D-glucan (BDG) in populations with low prevalence of invasive fungal infection (IFI), such as hematologic patients receiving antimold prophylaxis, should be re-evaluated. Methods. We retrospectively reviewed episodes with BDG results in hematologic patients receiving antimold prophylaxis from January 2017 to August 2019 in a tertiary hospital. The episodes were classified as true positive ([TP] positive BDG with IFI), true negative ([TN] negative BDG without IFI), false positive ([FP] positive BDG without IFI), false negative ([FN] negative BDG with IFI), and nonevaluable. Results. A total of 203 episodes were analyzed: 101 episodes (49.8%) were from stem cell transplants, 89 (43.8%) were from induction chemotherapy, and 13 (6.4%) were from graft-versus-host disease treatment. There were 62 nonevaluable episodes. Among 141 evaluable ones, there were 8 (5.7%) episodes of probable/proven IFI. True positive, TN, FP, and FN cases were 4 (2.8%), 112 (79.4%), 21 (14.9%), and 4 (2.8%) episodes, respectively. Sensitivity, specificity, positive predictive value, and negative predictive value were 50.0%, 84.2%, 16.1%, and 96.5%, respectively. Positive predictive value was 26.7% and 0.0% in diagnostic and surveillance episodes, respectively. Conclusions. beta-D-glucan test should be used to exclude IFI rather than for diagnosis in these patients. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Limited Positive Predictive Value of β-D-Glucan in Hematologic Patients Receiving Antimold Prophylaxis | - |
dc.title.alternative | Limited Positive Predictive Value of beta-D-Glucan in Hematologic Patients Receiving Antimold Prophylaxis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/ofid/ofaa048 | - |
dc.citation.journaltitle | Open Forum Infectious Diseases | - |
dc.identifier.wosid | 000522853100006 | - |
dc.identifier.scopusid | 2-s2.0-85087424012 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | ofaa048 | - |
dc.citation.volume | 7 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hong, Junshik | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Kim, Nam-Joong | - |
dc.contributor.affiliatedAuthor | Yoon, Sung-Soo | - |
dc.contributor.affiliatedAuthor | Kim, Inho | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-don | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INVASIVE FUNGAL-INFECTIONS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | 1,3-BETA-D-GLUCAN | - |
dc.subject.keywordPlus | ASPERGILLOSIS | - |
dc.subject.keywordPlus | GALACTOMANNAN | - |
dc.subject.keywordPlus | FLUCONAZOLE | - |
dc.subject.keywordPlus | ANTIGENEMIA | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordAuthor | antimold prophylaxis | - |
dc.subject.keywordAuthor | beta-d-glucan | - |
dc.subject.keywordAuthor | fungal diagnostics | - |
dc.subject.keywordAuthor | hematologic diseases | - |
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