Detailed Information

A Prospective Cohort Study of Durations of Staphylococcus aureus Bacteremia According to Different Phenotypes and a New Concept of Persistent Bacteremia

Cited 1 time in Web of Science Cited 3 time in Scopus

Kang, Chang Kyung; Song, Kyoung-Ho; Kim, Seong Eun; Kim, Eu Suk; Park, Wan Beom; Park, Kyung-Hwa; Chun, Shin Hye; Lee, Shinwon; Cho, Chong Rae; Kang, Seung Ji; Oh, Myoung-don; Kim, Yeon-Sook; Lee, Sun Hee; Kwak, Yee Gyung; Jang, Hee-Chang; Kim, Chung-Jong; Kim, Young Keun; Bang, Ji-Hwan; Kiem, Sungmin; Kwon, Ki Tae; Jung, Younghee; Kang, Yu Min; Jung, Sook-In; Kim, Hong Bin; Kim, Nam-Joong; Choe, Pyoeng Gyun; Kim, Taek Soo; Choi, Su Jin; Park, Kyoung Un; Choi, Yun Jung; Kwon, Kyoung Mi; Park, Jung In; Choi, Su-Mi; Yun, Seon Jin; Yi, Jongyoun; Park, Sohee; Hwang, Hyeon-jeong; Lee, Youngsoon; Choi, Hee Kyoung; Han, Myung Sook; Park, Sang Won; Kim, Dong-Kie; Song, Sae-Am; Kang, Min Ji; Shin, Jae Gyun; Kim, Hye-In; Shin, Seung Min

Issue Date
American Society for Microbiology
Antimicrobial Agents and Chemotherapy, Vol.64 No.1, p. e01656-19
The purpose of this study was to describe and compare the duration of Staphylococcus aureus bacteremia (SAB) according to methicillin resistance and the primary foci of infection. We also aimed to newly define persistent SAB considering these results. Nonduplicated episodes of SAB in patients aged >= 15 years from 14 hospitals in the Republic of Korea were analyzed between January 2009 and February 2018. The duration of SAB was defined as the number of days from the time of administration of an antibiotic to which the isolate was susceptible after the onset of SAB to the last day of a positive blood culture for S. aureus. SAB durations were described and compared based on methicillin resistance and the primary foci of infection. Cases in the top quartile for the duration of bacteremia in the respective clinical context were classified as newly defined persistent SAB, and its association with in-hospital mortality was evaluated. A total of 1,917 cases were analyzed. The duration of SAB was longer in patients with methicillin-resistant SAB (MRSAB; n = 995) than in patients with methicillin-susceptible SAB (MSSAB; n = 922) (median duration, 1 day [interquartile range, 1 to 3 days] for MSSAB and 1 day [interquartile range, 0 to 5 days] for MRSAB; P < 0.001). The duration of bacteremia was longer in patients with endocarditis and bone and joint, endovascular, and surgical site infections and was shorter in patients with skin and soft tissue infections. Newly defined persistent SAB was independently associated with in-hospital mortality (adjusted odds ratio, 1.97; 95% confidence interval, 1.54 to 2.53; P < 0.001). The durations of SAB were dependent on methicillin resistance and the primary foci of infection, and considering these contexts, persistent SAB was significantly associated with in-hospital mortality.
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Medicine
  • Department of Medicine
Research Area Immunology, Infectious Diseases, Vaccination, 감염병, 바이러스질환, 예방접종


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.