Publications
Detailed Information
Sensitive and specific detection of low-level antibody responses in mild Middle East respiratory syndrome coronavirus infections
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Okba, Nisreen M. A. | - |
dc.contributor.author | Raj, V. Stalin | - |
dc.contributor.author | Widjaja, Ivy | - |
dc.contributor.author | GeurtsvanKessel, Corine H. | - |
dc.contributor.author | de Bruin, Erwin | - |
dc.contributor.author | Chandler, Felicity D. | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Nam-Joong | - |
dc.contributor.author | Farag, Elmoubasher A. B. A. | - |
dc.contributor.author | Al-Hajri, Mohammed | - |
dc.contributor.author | Bosch, Berend-Jan | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Koopmans, Marion P. G. | - |
dc.contributor.author | Reusken, Chantal B. E. M. | - |
dc.contributor.author | Haagmans, Bart L. | - |
dc.date.accessioned | 2024-04-26T01:02:28Z | - |
dc.date.available | 2024-04-26T01:02:28Z | - |
dc.date.created | 2020-02-14 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | Emerging Infectious Diseases, Vol.25 No.10, pp.1868-1877 | - |
dc.identifier.issn | 1080-6040 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199638 | - |
dc.description.abstract | Middle East respiratory syndrome coronavirus (MERS-CoV) infections in humans can cause asymptomatic to fatal lower respiratory lung disease. Despite posing a probable risk for virus transmission, asymptomatic to mild infections can go unnoticed; a lack of seroconversion among some PCR-confirmed cases has been reported. We found that a MERS-CoV spike S1 protein-based ELISA, routinely used in surveillance studies, showed low sensitivity in detecting infections among PCR-confirmed patients with mild clinical symptoms and cross-reactivity of human coronavirus OC43-positive serum samples. Using in-house S1 ELISA and protein microarray, we demonstrate that most PCR-confirmed MERS-CoV case-patients with mild infections seroconverted; nonetheless, some of these samples did not have detectable levels of virus-neutralizing antibodies. The use of a sensitive and specific serologic Si-based assay can be instrumental in the accurate estimation of MERS-CoV prevalence. | - |
dc.language | 영어 | - |
dc.publisher | US National Center for Infectious Diseases | - |
dc.title | Sensitive and specific detection of low-level antibody responses in mild Middle East respiratory syndrome coronavirus infections | - |
dc.type | Article | - |
dc.identifier.doi | 10.3201/eid2510.190051 | - |
dc.citation.journaltitle | Emerging Infectious Diseases | - |
dc.identifier.wosid | 000490017300010 | - |
dc.identifier.scopusid | 2-s2.0-85072354827 | - |
dc.citation.endpage | 1877 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 1868 | - |
dc.citation.volume | 25 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Kim, Nam-Joong | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-don | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MERS-COV INFECTION | - |
dc.subject.keywordPlus | DROMEDARY CAMELS | - |
dc.subject.keywordPlus | SEROLOGICAL ASSAYS | - |
dc.subject.keywordPlus | SAUDI-ARABIA | - |
dc.subject.keywordPlus | SOUTH-KOREA | - |
dc.subject.keywordPlus | OUTBREAK | - |
dc.subject.keywordPlus | HUMANS | - |
dc.subject.keywordPlus | RISK | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.