Microevolution of outbreak-associated middle east respiratory syndrome coronavirus, south korea, 2015

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Microevolution of outbreak-associated middle east respiratory syndrome coronavirus, south korea, 2015

Cited 24 time in Web of Science Cited 27 time in Scopus

Authors: Seong, Moon -Woo; Kim, So Yeon; Corman, Victor Max; Kim, Taek Soo; Cho, Sung Im; Kim, Man Jin; Lee, Seung Jun; Lee, Jee-Soo; Seo, Soo Hyun; Ahn, Ji Soo; Yu, Byeong Su; Park, Nare; Oh, Myoung-don; Park, Wan Beom; Lee, Ji Yeon; Kim, Gayeon; Joh, Joon Sung; Jeong, Ina; Kim, Eui Chong; Drosten, Christian; Park, Sung Sup

Abstract: During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary rate and no reason to suspect adaptive changes in viral proteins.